| 陈勇,卢中一,靳远,韩黎,黄留玉.烟曲霉对唑类药物耐药研究的最新进展[J].Chinese journal of Epidemiology,2016,37(12):1687-1692 |
| 烟曲霉对唑类药物耐药研究的最新进展 |
| Progress of research on azole resistance in Aspergillus fumigatus |
| Received:July 28, 2016 |
| DOI：10.3760/cma.j.issn.0254-6450.2016.12.025 |
| KeyWord: 烟曲霉 唑类药物 耐药 流行病学 进化 |
| English Key Word: Aspergillus fumigatus Azole drugs Drug resistance Epidemiology Evolution |
| FundProject:生物安全关键技术研发重点专项（2016YFC1200100） |
| Author Name | Affiliation | E-mail | | Chen Yong | Department of Hospital Infection Control, Institute of Disease Control and Prevention, Academy of Military Medical Science, Beijing 100071, China | | | Lu Zhongyi | Department of Hospital Infection Control, Institute of Disease Control and Prevention, Academy of Military Medical Science, Beijing 100071, China | | | Jin Yuan | Department of Bioinformatics, Institute of Biotechnology, Academy of Military Medical Science, Beijing 100071, China | | | Han Li | Department of Hospital Infection Control, Institute of Disease Control and Prevention, Academy of Military Medical Science, Beijing 100071, China | hanlicdc@163.com | | Huang Liuyu | Department of Infectious Disease, Institute of Disease Prevention and Control, Academy of Military Medical Science, Beijing 100071, China | |
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| Abstract: |
| 烟曲霉是一种重要的临床致病真菌，可引发致死性霉菌感染。唑类药物是治疗各类曲霉病的临床一线药物。近年来，全世界范围内烟曲霉对唑类药物耐药的报道不断增加，严重影响临床和农药唑类药物使用的有效性，已成为一个重要公共卫生问题。本文主要对烟曲霉唑类药物耐药的流行现状、耐药分子机制、耐药产生的原因、耐药株的进化规律以及防控措施等分别进行介绍。 |
| English Abstract: |
| Being an important clinical fungal pathogen, Aspergillus (A.) fumigatus can cause fatal invasive fungal infections. Azoles are the first line drugs in treating various Aspergillus-caused diseases. Worldwidely, reports related to azole resistance in A. fumigatus have been increasing which posing a threat on the effectiveness of clinically used azole and agricultural fungicides. Currently, it has become an important public health issue. In this review, we summarize findings from literature regarding the following areas:the occurrence of azole resistance in A. fumigatus, the molecular mechanisms of resistance, contributing factors for the emergence of azole resistance, evolution of resistant strains and related control and prevention measures. |
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