| 肖民扬,陈晓明,马艳玲,付丽茹,牛瑾,陈志娟,李洪元,王芹丽,宋丽军,罗红兵.云南省大理市大规模社区人群2014-2015年艾滋病队列研究[J].Chinese journal of Epidemiology,2017,38(7):916-920 |
| 云南省大理市大规模社区人群2014-2015年艾滋病队列研究 |
| A large scale cohort study on AIDS in communities in Dali, Yunnan province, 2014-2015 |
| Received:January 17, 2017 |
| DOI：10.3760/cma.j.issn.0254-6450.2017.07.014 |
| KeyWord: 艾滋病 社区人群 队列研究 |
| English Key Word: AIDS Community population Cohort study |
| FundProject:国家科技重大专项（2013ZX10004-906） |
| Author Name | Affiliation | E-mail | | Xiao Minyang | Center for AIDS/STDs Prevention and Control, Yunnan Provincial Center for Disease Control and Prevention, Kunming 650022, China | | | Chen Xiaoming | Dali Bai Autonomous Prefecture Center for Disease Control and Prevention, Dali 671099, China | | | Ma Yanling | Center for AIDS/STDs Prevention and Control, Yunnan Provincial Center for Disease Control and Prevention, Kunming 650022, China | | | Fu Liru | Center for AIDS/STDs Prevention and Control, Yunnan Provincial Center for Disease Control and Prevention, Kunming 650022, China | | | Niu Jin | Center for AIDS/STDs Prevention and Control, Yunnan Provincial Center for Disease Control and Prevention, Kunming 650022, China | | | Chen Zhijuan | Dali Bai Autonomous Prefecture Center for Disease Control and Prevention, Dali 671099, China | | | Li Hongyuan | Dali City Center for Disease Control and Prevention, Dali 671099, China | | | Wang Qinli | Dali City Center for Disease Control and Prevention, Dali 671099, China | | | Song Lijun | Center for AIDS/STDs Prevention and Control, Yunnan Provincial Center for Disease Control and Prevention, Kunming 650022, China | | | Luo Hongbing | Center for AIDS/STDs Prevention and Control, Yunnan Provincial Center for Disease Control and Prevention, Kunming 650022, China | 540122323@qq.com |
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| Abstract: |
| 目的 了解云南省大理市社区人群HIV新发感染率和新发感染特点。方法 采用队列研究，将2010-2011年大理市HIV检测为阴性的146 720人纳入队列，2014年6月至2015年5月进行追踪检测。结果 共随访检测136 356人，随访率为92.9%（136 356/146 720），随访时间M为3.43（0.23~5.40）年，累积随访时间为459 675人年， HIV阳性78例，HIV新发感染率为0.170/1 000人年。HIV新发感染率按年龄组：15~29岁组为0.037/1 000人年，30~44岁组为0.288/1 000人年，45~59岁组为0.210/1 000人年， ≥ 60岁组为0.204/1 000人年；HIV新发感染率按性别：男性为0.213/1 000人年，女性为0.130/1 000人年；HIV新发感染率按民族：汉族为0.248/1 000人年，少数民族为0.149/1 000人年；HIV新发感染率按文化程度：初中及以下者为0.194/1 000人年，初中以上者0.046/1 000人年；HIV新发感染率按婚姻状况：未婚者为0.070/1 000人年，已婚者为0.194/1 000人年，离婚/丧偶者为0.425/1 000人年。Cox比例风险回归分析结果显示，男性（HR=1.731），30~44岁组（HR=13.158），45~59岁组（HR=10.329）， ≥ 60岁组（HR=8.291），未婚者（HR=3.162）及离婚/丧偶（HR=2.689）为HIV感染的危险因素，初中以上文化程度者（HR=0.132）为保护因素。结论 经过M=3.43年的随访，大理市社区人群的HIV新发感染率为0.170/1 000人年，男性、30岁以上、文化程度较低、未婚、离婚/丧偶者为艾滋病新发感染率的危险因素。应重点针对以上人群开展艾滋病防控工作。 |
| English Abstract: |
| Objective To understand HIV incidence in community residents and epidemiological characteristics of newly detected HIV infection cases in Dali, Yunnan province. Methods A cohort study was conducted among 146 720 community residents who were tested to be HIV negative during 2010-2011, they were followed-up from June 1, 2014 to May 31, 2015. Results A total of 136 356 community residents received follow up (92.9%). The follow-up time was 0.23-5.40 years (medium:3.43 years), cumulatively 459 675 person years, and 78 people were found to be HIV positive. The incidence rate of HIV infection was 0.170/1 000 person years. The incidence rate was 0.037/1 000 person years in age group 15-29 years, 0.288/1 000 person years in age group 30-44 years, 0.210/1 000 person years in age group 45-59 years, 0.204/1 000 person years in age ≥ 60 years; 0.213/1 000 person years in males, 0.130/1 000 person years in females; 0.248/1 000 person years in Han ethnic group, 0.149/1 000 person years in Minorities; 0.194/1 000 in people with education level ≤ junior middle school, 0.046/1 000 person years in people with education level > junior middle school; 0.070/1 000 person years in the unmarried, 0.194/1 000 person years in the married and 0.425/1 000 person years in the divorced/widowed. Cox proportional hazards regression analysis showed that being male (HR=1.731), aged 30-44 years (HR=13.158), aged 45-59 years (HR=10.329), aged ≥ 60 years (HR=8.291), unmarried (HR=3.162) and divorced/widowed (HR=2.689) were the risk factors for HIV infection, while the education level > junior middle school (HR=0.132) was the protective factor for HIV infection. Conclusions By medium 3.43 years follow up, the cohort study showed that incidence rate HIV infection was 0.170/1 000 person years in the community residents in Dali. Male, middle aged and old people, people with low education level, the unmarried and the divorced/widowed had relatively higher risk to be infected with HIV, Close attention should be paid to the prevention and control of AIDS in these populations. |
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