| 刘佳,王哲.肠道微生物群与艾滋病疾病进展[J].Chinese journal of Epidemiology,2017,38(8):1145-1150 |
| 肠道微生物群与艾滋病疾病进展 |
| Intestinal microbiota and progression of AIDS |
| Received:March 14, 2017 |
| DOI：10.3760/cma.j.issn.0254-6450.2017.08.030 |
| KeyWord: 艾滋病 肠道微生物群 疾病进展 |
| English Key Word: AIDS Intestinal microbiota Disease progression |
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| Abstract: |
| 抗病毒治疗能够降低艾滋病的发病率和死亡率，但近年来的研究发现即便在抗病毒治疗成功抑制病毒血症的情况下，肠道的免疫失调和其引发的结构性损伤引起了微生物易位，使机体产生免疫激活并形成相关炎症，导致艾滋病的疾病进展。肠道微生物群对于保持肠道黏膜屏障的功能、调节固有免疫、获得性免疫以及保持肠道的平衡状态都非常重要。因此，探讨肠道微生物群的变化与艾滋病疾病进展的关系，有很重要的理论价值和现实意义。本文着重探讨肠道微生物群与艾滋病的疾病进展相关的各项研究以及应用于艾滋病治疗的可能。 |
| English Abstract: |
| Antiretroviral treatment has significantly reduced the mortality and morbidity of AIDS. However, recent studies have shown that when HIV viremia is successfully inhibited by antiretroviral treatment, intestinal immune disorders and secondary structural damage can still bring out microbial translocation which give rise to immune activation and the related inflammation will later lead to the progression of AIDS disease. Since intestinal microbiota is important for maintaining the function of the intestinal mucosal barrier, regulating innate immunity/acquired immunity and maintaining intestinal balance, studies on the relationship between changes in intestinal microbiota and the progression AIDS disease are of significantly theoretical value and practical meaning. This review focuses on the relationship between intestinal microbiota and the progressive AIDS, as well as the potential of application in treatment. |
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