张维璐,吉兆华,付婷,张磊,苏海霞,闫永平.中国2007-2016年59岁以下普通人群HBsAg阳性率的Meta分析[J].Chinese journal of Epidemiology,2017,38(9):1278-1284 |
中国2007-2016年59岁以下普通人群HBsAg阳性率的Meta分析 |
Meta analysis on HBsAg-positive rate among general populations aged 1-59 years, 2007-2016, China |
Received:October 14, 2016 |
DOI:10.3760/cma.j.issn.0254-6450.2017.09.027 |
KeyWord: 乙型肝炎表面抗原 阳性率 Meta分析 |
English Key Word: HBsAg Positive rate Meta-analysis |
FundProject:国家自然科学基金(81473026,81302474);国家科技重大专项(2012ZX10004907);陕西省社发攻关项目(2016SF-131) |
Author Name | Affiliation | E-mail | Zhang Weilu | Department of Epidemiology, School of Public Health, The Fourth Military Medical University, Xi'an 710032, China | | Ji Zhaohua | Department of Epidemiology, School of Public Health, The Fourth Military Medical University, Xi'an 710032, China | | Fu Ting | Department of Epidemiology, School of Public Health, The Fourth Military Medical University, Xi'an 710032, China | | Zhang Lei | Department of Epidemiology, School of Public Health, The Fourth Military Medical University, Xi'an 710032, China | | Su Haixia | Department of Epidemiology, School of Public Health, The Fourth Military Medical University, Xi'an 710032, China | | Yan Yongping | Department of Epidemiology, School of Public Health, The Fourth Military Medical University, Xi'an 710032, China | yanyping@fmmu.edu.cn |
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Abstract: |
目的 采用Meta分析方法系统评价2007-2016年中国59岁以下普通人群HBsAg阳性率的变化趋势。方法 通过中国知网(CNKI)、维普中文科技期刊全文数据库(VIP)及PubMed,系统检索2007年1月至2016年8月中国59岁以下普通人群HBsAg阳性率的文献,采用comprehensive Meta-analysis 2.2软件,运用固定效应模型和随机效应模型合并分析59岁以下普通人群HBsAg阳性率。结果 共纳入文献46篇,总样本量625 053例,Meta分析结果显示中国59岁以下普通人群HBsAg阳性率为5.7%(95%CI:4.8%~6.6%)。中西部地区59岁以下普通人群HBsAg阳性率为6.3%(95%CI:4.9%~8.0%),高于东部地区的5.5%(95%CI:4.4%~6.8%)。59岁以下男性人群HBsAg阳性率为6.1%(95%CI:5.3%~7.0%),高于女性人群的4.8%(95%CI:4.2%~5.5%)。2007-2009年的59岁以下普通人群HBsAg阳性率为6.3%(95%CI:5.5%~7.2%),2010-2012年为5.9%(95%CI:4.4%~8.0%),2013-2016年为3.5%(95%CI:2.0%~6.1%)。结论 2007-2016年中国59岁以下普通人群HBsAg阳性率呈现下降趋势,已经从乙型肝炎高流行区转变为乙型肝炎中流行区。 |
English Abstract: |
Objective To perform a Meta-analysis on hepatitis B surface antigen (HBsAg)-positive rates among general Chinese population aged 1-59 years. Methods We systemically reviewed the related data (January 2007 to August 2016) published from Chinese National Knowledge Infrastructure (CNKI), VIP, and PubMed. We also assessed the HBsAg-positive rates among general Chinese populations aged 1-59 years, using a random effects regression model with the comprehensive Meta-analysis software 2.2. Results A total of 46 papers were finally included, with a total sample size of 625 053 individuals. Results from the Meta-analysis showed that the overall combined HBsAg-positive rate was 5.7% (95%CI:4.8%-6.6%) among general Chinese populations aged 1-59 years. When comparing the HBsAg-positive rates in different regions, data showed that the HBsAg-positive rate of was higher in the mid-western areas (6.3%, 95%CI:4.9%-8.0%) than in the eastern areas (5.5%, 95%CI:4.4%-6.8%). Results showed that HBsAg-positive rates was higher in males (6.1%, 95%CI:5.3%-7.0%) than in females (4.8%, 95%CI:4.2%-5.5%). As for the HBsAg-positive rates in different time periods, data showed positive rate of 6.3% (95%CI:5.5%-7.2%) in 2007-2009, 5.9% (95%CI:4.4%-8.0%) in 2010-2012 and 3.5% (95%CI:2.0%-6.1%) in 2013-2016, respectively. Conclusion The prevalence of hepatitis B virus infection was decreasing between 2007 and 2016 in China, making the country an intermediate endemic area on HBV. |
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