上海市艾滋病自愿咨询检测门诊男男性行为者HIV与梅毒、单纯疱疹病毒2型共感染状况调查

刘瑛; 唐海丰; 宁镇; 郑煌; 何纳; 张宇艳

Abstract

刘瑛,唐海丰,宁镇,郑煌,何纳,张宇艳.上海市艾滋病自愿咨询检测门诊男男性行为者HIV与梅毒、单纯疱疹病毒2型共感染状况调查[J].Chinese journal of Epidemiology,2017,38(10):1363-1366

上海市艾滋病自愿咨询检测门诊男男性行为者HIV与梅毒、单纯疱疹病毒2型共感染状况调查

Co-infections of HIV, syphilis and HSV-2 among men who have sex with men at the voluntary HIV counseling and testing clinics in Shanghai

Received:March 20, 2017

DOI：10.3760/cma.j.issn.0254-6450.2017.10.013

KeyWord: 男男性行为者 HIV 梅毒单纯疱疹病毒2型共感染

English Key Word: MSM HIV Syphilis Herpes simples virus Ⅱ Co-infection

FundProject:上海市卫生和计划生育委员会科研课题（201540066）；上海市普陀区卫生系统"315"工程人才培养计划

Author Name	Affiliation	E-mail
Liu Ying	Putuo District Center for Disease Control and Prevention, Shanghai 200333, China School of Public Health, The Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai 200032, China
Tang Haifeng	Putuo District Center for Disease Control and Prevention, Shanghai 200333, China
Ning Zhen	Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, China
Zheng Huang	Shanghai Piaoxue Cultural Media Limited, Shanghai 200023, China
He Na	School of Public Health, The Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai 200032, China	nhe@shmu.edu.cn
Zhang Yuyan	Putuo District Center for Disease Control and Prevention, Shanghai 200333, China	ayishe_zh@126.com

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Abstract:

目的了解上海市艾滋病自愿咨询检测（VCT）门诊就诊MSM人群HIV与梅毒、单纯疱疹病毒2型（HSV-2）共感染情况及其可能影响因素。方法采用横断面研究设计，用方便抽样法选取上海市与普陀区的2个VCT门诊，于2015年3-8月招募≥ 18岁、最近1年发生过同性插入性性行为的MSM作为调查对象，招募756名MSM，使用χ²检验和logistic回归法分析。结果共调查732名MSM，调查对象HIV与梅毒共感染率为3.3%（24/732），HIV与HSV-2共感染率为1.9%（14/732），HIV与梅毒、HSV-2共感染率为0.7%（5/732）。梅毒感染者的HIV感染率45.3%（24/53）显著高于非梅毒感染者7.2%（61/679）（χ²=63.11，P<0.001）；HSV-2感染者的HIV感染率34.1%（14/41）显著高于非HSV-2感染者10.3%（71/691）（χ²=21.49，P<0.001）。多因素logistic回归分析显示，调查对象HIV与梅毒共感染的可能危险因素包括外地户籍（OR=3.50，95% CI：1.01~12.17）、初中及以下文化程度（OR=4.46，95% CI：1.54~12.87）和曾使用毒品（OR=4.25，95% CI：1.67~10.82）；HIV与HSV-2共感染的可能危险因素：高中及以下文化程度（OR=6.87，95% CI：1.86~25.42；OR=9.82，95% CI：2.25~42.85）。结论上海市VCT门诊就诊的MSM中存在一定比例的HIV和梅毒、HIV和HSV-2共感染情况。应关注外来务工人员、文化程度低者和使用毒品者。

English Abstract:

Objective To understand the prevalence rates of HIV-syphilis and HIV-herpes simplex virus 2 (HSV-2) co-infections and related factors among men having sex with men (MSM) who had visited the voluntary HIV counseling and testing (VCT) clinics in Shanghai, China. Methods 756 eligible MSM who attended the VCT clinics of Shanghai Municipality and Putuo district during March to August, 2015 were recruited to participate in a cross-sectional survey with questionnaire interview and blood testing for HIV, syphilis and HSV-2. Results A total of 732 participants completed a valid questionnaire survey. The prevalence rates were 3.3% (24/732) for HIV/Syphilis co-infection, 1.9% (14/732) for HIV/HSV-2 co-infection, and 0.7% (5/732) for HIV/Syphilis/HSV-2 co-infection, respectively. HIV prevalence appeared significantly higher among syphilis-infected participants (45.3%, 24/53) than those without Syphilis (7.2%, 61/679) (χ²=63.11, P<0.001), and was also significantly higher among HSV-2 infected participants (34.1%, 14/41) than those without the HSV-2 infection (10.3%, 71/691) (χ²=21.49, P<0.001). Results from the Multivariate regression analysis indicated that participants who were migrants (OR=3.50, 95% CI:1.01-12.17), having had middle school or lower levels of education (OR=4.46, 95% CI:1.54-12.87) or ever used illicit drugs (OR=4.25, 95% CI:1.67-10.82, P=0.002) were under possible risks on HIV and Syphilis co-infection. Those participants who had high middle school or lower levels of education (OR=6.87, 95% CI:1.86-25.42; OR=9.82, 95% CI:2.25-42.85) were under risk on HIV and HSV-2 co-infection. Conclusion HIV/Syphilis and HIV/HSV-2 co-infection were seen among MSM who attended the VCT clinics in Shanghai that called for special attention, especially on migrants, those with low education or illicit drug users.

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