临床结局观察性研究中的领先时间偏倚及控制

张娜; 刘慧鑫; 康殿民; 汪宁

Abstract

张娜,刘慧鑫,康殿民,汪宁.临床结局观察性研究中的领先时间偏倚及控制[J].Chinese journal of Epidemiology,2018,39(5):700-703

临床结局观察性研究中的领先时间偏倚及控制

Lead time bias and its control in observational studies for clinical outcomes

Received:October 10, 2017

DOI：10.3760/cma.j.issn.0254-6450.2018.05.032

KeyWord: 观察性研究领先时间偏倚控制高效抗反转录病毒治疗临床结局

English Key Word: Observational study Lead time bias Control Highly active antiretroviral therapy Clinical outcome

FundProject:山东省自然科学基金青年基金（ZR2014HQ038）；国家自然科学基金（81602939）

Author Name	Affiliation	E-mail
Zhang Na	National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China Institute for AIDS Control and Prevention, Shandong Provincial Center for Disease Control and Prevention, Jinan 250014, China
Liu Huixin	Peking University People's Hospital, Beijing 100044, China
Kang Dianmin	Institute for AIDS Control and Prevention, Shandong Provincial Center for Disease Control and Prevention, Jinan 250014, China	dmkang66@163.com
Wang Ning	National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China	wangnbj@163.com

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Abstract:

临床结局观察性研究中可能存在领先时间偏倚。本文以筛检诊断试验对肿瘤患者生存时间的影响研究、高效抗反转录病毒治疗对HIV/AIDS生存时间的影响研究，两个实例阐述领先时间偏倚的概念、产生原因及控制，为准确分析评价检测、治疗等干预措施对存在多个疾病病程或分期疾病的作用效果时提供控制该偏倚的思路和方法。

English Abstract:

Lead time bias might exist in observational study for clinical outcomes. This paper summarizes the concept of lead time bias, causes and control of lead time bias by using the studies of influences of screening diagnostic test on cancer patients'survival and highly active antiretroviral therapy on HIV/AIDS patients' survival as examples for the purpose of providing thinking and methods in the control of lead time bias for the accurate evaluation of the effects of interventions, such as test and treatment, on the diseases with multi courses or phases.

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