Abstract
吉宁,王黎君,刘世炜,刘敏,曾新颖,周脉耕.1990年与2016年中国女性子宫纤维瘤的疾病负担研究[J].Chinese journal of Epidemiology,2019,40(2):160-164
1990年与2016年中国女性子宫纤维瘤的疾病负担研究
Disease burden on uterine fibroids in China, 1990 and 2016
Received:September 02, 2018  
DOI：10.3760/cma.j.issn.0254-6450.2019.02.007
KeyWord: 子宫纤维瘤  疾病负担  中国
English Key Word: Uterine fibroids  Disease burden  China
FundProject:
Author NameAffiliationE-mail
Ji Ning Division of Health Promotion and Intervention, National Center for Chronic and Non-communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100050, China  
Wang Lijun Division of Vital Registry and Mortality Surveillance, National Center for Chronic and Non-communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100050, China  
Liu Shiwei Division of Comprehensive Prevention and Evaluation, National Center for Chronic and Non-communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100050, China  
Liu Min Division of Health Promotion and Intervention, National Center for Chronic and Non-communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100050, China  
Zeng Xinying Division of Vital Registry and Mortality Surveillance, National Center for Chronic and Non-communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100050, China  
Zhou Maigeng National Center for Chronic and Non-communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100050, China maigengzhou@126.com 
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Abstract:
      目的 分析1990年与2016年中国女性子宫纤维瘤的疾病负担。方法 利用2016年全球疾病负担分析结果，分析1990年和2016年中国不同年龄、不同地区女性子宫纤维瘤的疾病负担，主要指标包括患病数、患病率、伤残调整寿命年（DALY）、DALY率等。标化率的计算使用2010-2035年WHO的世界标准人口进行。结果 1990年和2016年中国≥ 15岁女性子宫纤维瘤的患病人数分别为13 695 567和27 169 312人，患病率分别为2.48%和4.10%，DALY值分别为146 045.05人年和281 976.67人年，DALY率分别为26.40/10万和42.50/10万。1990年和2016年中国女性子宫纤维瘤的患病率和DALY率均随年龄增加而增加，45~49岁达顶峰，之后随年龄增加而降低。中国女性子宫纤维瘤40~54岁年龄段的患病数占总量的55.60%（1990年）和66.74%（2016年）；该年龄段DALY值占总量的48.37%（1990年）和60.65%（2016年）。1990年和2016年DALY值较高的3个省份均为山东（1990年：12 574.67人年；2016年：22 728.12人年）、河南（1990年：10 849.29人年；2016年：18 454.32人年）和江苏（1990年：10 501.55人年；2016年：18 274.10人年），标化DALY率较高的3个省份在1990年和2016年均为黑龙江（1990年：48.20/10万；2016年：47.00/10万）、山西（1990年：44.50/10万；2016年：47.70/10万）和天津（1990年：43.80/10万；2016年：46.40/10万）。与1990年相比，2016年中国女性子宫纤维瘤的患病人数增加13 473 745人（变化率：98.38%），标化患病相对上升1.88%、DALY值增加135 931.62人年（变化率：93.08%）、标化DALY率相对上升5.92%。结论 2016年中国女性子宫纤维瘤疾病负担较1990年明显增加，尤其困扰绝经期女性。
English Abstract:
      Objective To assess the disease burden on uterine fibroids in China in 1990 and 2016. Methods Data were extracted from the Global Burden of Disease Study 2016. Burdens of uterine fibrosis among different age groups and provinces were measured in 1990 and 2016, with key indicators including number of cases, prevalence rates, disability-adjusted life year (DALY) and the rates of DALY. The WHO world standard population, 2010-2035 was used to calculate the age-standardized rates. Results In 1990 and 2016, there were 13 695 567 and 27 169 312 women aged 15 years and older, suffered from uterine fibrosis respectively, with prevalence rate as 2.48% and 4.10%, DALY as 146 045.05 life years and 281 976.67 life years, and the DALY rate as 26.40/100 000 and 42.50/100 000, in 1990 and 2016 respectively. Both the prevalence rate and the DALY rate increased with age, reaching the peak on the 45-49 years-old, in both 1990 and 2016. Women aged 40-54 years accounted for 55.60% (1990) and 66.74% (2016) of the total cases while 48.37% (1990) and 60.65% (2016) of the total DALY. The first three provinces with highest DALYs were Shandong (1990:12 574.67 life year; 2016:22 728.12 life year), Henan (1990:10 849.29 life year; 2016:18 454.32 life year) and Jiangsu (1990:10 501.55 life year; 2016:18 274.10 life year), while the three provinces with leading standardized DALY rates were Heilongjiang (1990:48.20/100 000; 2016:47.00/100 000), Shanxi (1990:44.50/100 000; 2016:47.70/100 000) and Tianjin (1990:43.80/100 000; 2016:46.40/100 000) in both 1990 and 2016. Compared with 1990, the number of cases with uterine fibroids increased by 13 473 745 (with rate of change as:98.38%), standardized prevalence rate increased by 1.88%, DALY value increased by 135 931.62 life years (with the rate of change as 93.08%) and standardized DALY rate increased by 5.92% among Chinese women, in 2016. Conclusion Menopausal women were the ones hard hit by uterine fibrosis. Compared with data from 1990, the disease burden of uterine fibrosis increased rapidly in China, in 2016.
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