学龄前儿童邻苯二甲酸酯暴露的累积风险评估

高慧; 黄锟; 伍晓艳; 蔡秀秀; 韩艳; 朱鹏; 郝加虎; 陶芳标

Abstract

高慧,黄锟,伍晓艳,蔡秀秀,韩艳,朱鹏,郝加虎,陶芳标.学龄前儿童邻苯二甲酸酯暴露的累积风险评估[J].Chinese journal of Epidemiology,2019,40(5):585-589

学龄前儿童邻苯二甲酸酯暴露的累积风险评估

Cumulative risk assessment of phthalates exposure in preschool children

Received:September 21, 2018

DOI：10.3760/cma.j.issn.0254-6450.2019.05.018

KeyWord: 邻苯二甲酸酯学龄前儿童累积暴露风险评估危害指数

English Key Word: Phthalate Preschool children Cumulative risk assessment Hazard index

FundProject:国家自然科学基金（81330068）

Author Name	Affiliation	E-mail
Gao Hui	Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei 230032, China
Huang Kui	Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei 230032, China Anhui Provincial Key Laboratory of Population Health and Aristogenics, Hefei 230032, China
Wu Xiaoyan	Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei 230032, China Anhui Provincial Key Laboratory of Population Health and Aristogenics, Hefei 230032, China
Cai Xiuxiu	Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei 230032, China
Han Yan	Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei 230032, China
Zhu Peng	Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei 230032, China Anhui Provincial Key Laboratory of Population Health and Aristogenics, Hefei 230032, China
Hao Jiahu	Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei 230032, China Anhui Provincial Key Laboratory of Population Health and Aristogenics, Hefei 230032, China
Tao Fangbiao	Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei 230032, China Anhui Provincial Key Laboratory of Population Health and Aristogenics, Hefei 230032, China	fangbiaotao@126.com

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Abstract:

目的通过检测尿中邻苯二甲酸酯（PAEs）代谢物浓度，评估安徽省马鞍山市学龄前儿童累积暴露的健康风险。方法基于中国-安徽出生队列，2014年4月至2015年4月在安徽省马鞍山市采集3 743名儿童的基本信息和随机尿样。采用固相萃取-三重四级杆高效液相色谱串联质谱-同位素稀释法检测尿中5种PAEs［邻苯二甲酸二甲酯（DMP）；邻苯二甲酸二乙酯（DEP）和邻苯二甲酸二丁酯（DBP）；邻苯二甲酸丁苄酯（BBzP）；邻苯二甲酸单（2-乙基己）酯（DEHP）］的7种代谢物［邻苯二甲酸单甲酯（MMP）、邻苯二甲酸单乙酯（MEP）、邻苯二甲酸单丁酯（MBP）、邻苯二甲酸单苄酯（MBzP）、邻苯二甲酸单（2-乙基己）酯（MEHP）、邻苯二甲酸单（2-乙基-5-氧己基）酯（MEOHP）和邻苯二甲酸单（2-乙基-5-羟己基）酯（MEHHP）］浓度，根据代谢物浓度计算5种PAEs的每日估计暴露量。使用危害商（HQ）和危害指数（HI）法进行累积风险评估。结果 7种代谢物浓度M（Q_R）分别为29.58（18.69～48.26）、26.65（13.44～56.09）、256.86（150.99～438.51）、0.12（0.04～0.32）、6.27（3.71～11.13）、17.94（11.94～28.42）和24.80（16.05～40.32）μg/g肌酐。5种PAEs的每日估计暴露量从高到低依次为DBP、DEHP、DMP、DEP和BBzP，M依次为7.54（4.41～12.85）、3.35（2.20～5.42）、0.75（0.47～1.24）、0.71（0.36～1.52）和0.003（0.001～0.009）μg/（kg·d）。不同月龄、性别和采样季节间的HQ和HI差异有统计学意义（P<0.05）。结论马鞍山市3～6岁学龄前儿童PAEs累积暴露的健康风险较高，年龄、性别和季节是其影响因素。

English Abstract:

Objective The urine concentrations of phthalate metabolites were used to estimate the cumulative risk assessment in preschool children in Ma'anshan of Anhui province. Methods Based on the China-Anhui Birth Cohort, the demographic information and urine samples of 3 743 children were collected in Ma'anshan from April 2014 to April 2015. The concentrations of 7 metabolites'[monomethyl phthalate (MMP), monoethyl phthalate (MEP), monobutyl phthalate (MBP), monobenzyl phthalate (MBzP), mono (2-ethylhexyl) phthalate (MEHP), mono (2-ethyl-5-oxohexyl) phthalate (MEOHP) and mono (2-ethyl-5-hydroxyhexyl) phthalate (MEHHP)] of 5 phthalates[dimethyl phthalate (DMP), diethyl phthalate (DEP), dibutyl phthalate (DBP), butyl benzyl phthalate (BBzP), and di (2-ethylhexyl) phthalate (DEHP)] in the urine samples of the children were measured by solid-phase extration-triple quadrupole high performance liquid chromatography-tandem mass spectrometry-isotope method. In addition, the estimated daily intakes (EDIs) of 5 phthalates were calculated according to the metabolites' concentrations. Cumulative risk assessment was performed using hazard quotient (HQ) and hazard index (HI) methods. Results The M (Q_R) of seven metabolite concentrations were 29.58 (18.69-48.26), 26.65 (13.44-56.09), 256.86 (150.99-438.51), 0.12 (0.04-0.32), 6.27 (3.71-11.13), 17.94 (11.94-28.42) and 24.80 (16.05-40.32) μg/g creatinine, respectively. For the EDIs of 5 phthalates, DBP ranked first, followed by DEHP, DMP, DEP and BBzP with the M (Q_R) of 7.54 (4.41-12.85), 3.35 (2.20-5.42), 0.75 (0.47-1.24), 0.71 (0.36-1.52) and 0.003 (0.001-0.009) μg/(kg·d), respectively. The HQ and HI varied with age, gender and sampling season, the differences were significant (P<0.05). Conclusions These results indicated that risk of cumulative exposure to phthalates was high in preschool children aged 3-6 years in Ma'anshan. Age, gender and sampling season were influencing factors.

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