| 陈会超,王继宝,邢辉,马艳玲,段星,戴洁,金晓媚,姚仕堂,段松,陈敏.德宏傣族景颇族自治州2017年HIV-1感染者抗病毒治疗前耐药和病毒基因亚型研究[J].Chinese journal of Epidemiology,2019,40(8):982-987 |
| 德宏傣族景颇族自治州2017年HIV-1感染者抗病毒治疗前耐药和病毒基因亚型研究 |
| Study on HIV-1 genetics and drug resistance among HIV infected individuals who initiated antiretroviral therapy in Dehong Dai and Jingpo autonomous prefecture, 2017 |
| Received:February 27, 2019 |
| DOI：10.3760/cma.j.issn.0254-6450.2019.08.020 |
| KeyWord: 艾滋病病毒 基因型 耐药 抗病毒治疗 |
| English Key Word: HIV Genotype Drug resistance Antiretroviral therapy |
| FundProject:国家自然科学基金（81560327） |
| Author Name | Affiliation | E-mail | | Chen Huichao | Institute for AIDS/STD Control and Prevention, Yunnan Center for Disease Control and Prevention, Kunming 650022, China | | | Wang Jibao | Department of AIDS/STD Control and Prevention, Dehong Dai and Jingpo Autonomous Prefecture Center for Disease Control and Prevention, Mangshi 678400, China | | | Xing Hui | Division of Research on Virology and Immunology, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China | | | Ma Yanling | Institute for AIDS/STD Control and Prevention, Yunnan Center for Disease Control and Prevention, Kunming 650022, China | | | Duan Xing | Department of AIDS/STD Control and Prevention, Dehong Dai and Jingpo Autonomous Prefecture Center for Disease Control and Prevention, Mangshi 678400, China | | | Dai Jie | Institute for AIDS/STD Control and Prevention, Yunnan Center for Disease Control and Prevention, Kunming 650022, China | | | Jin Xiaomei | Institute for AIDS/STD Control and Prevention, Yunnan Center for Disease Control and Prevention, Kunming 650022, China | | | Yao Shitang | Department of AIDS/STD Control and Prevention, Dehong Dai and Jingpo Autonomous Prefecture Center for Disease Control and Prevention, Mangshi 678400, China | | | Duan Song | Department of AIDS/STD Control and Prevention, Dehong Dai and Jingpo Autonomous Prefecture Center for Disease Control and Prevention, Mangshi 678400, China | dhduansong@sina.com.cn | | Chen Min | Institute for AIDS/STD Control and Prevention, Yunnan Center for Disease Control and Prevention, Kunming 650022, China | chenminyx@126.com |
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| Abstract: |
| 目的 了解德宏傣族景颇族自治州（德宏州）抗病毒治疗（ART）前的HIV-1感染者基因型和耐药株的流行水平。方法 2017年1-6月在德宏州收集初始ART的HIV-1感染者170例，扩增pol基因，进行HIV-1基因分型和基因型耐药分析。结果 147份样品获得了pol基因，通过进化分析，发现12种HIV-1基因型，居于前3位包括C亚型（29.9%，44/147）、独特型重组形式（URFs）（27.2%，40/147）和CRF01_AE（19.7%，29/147），还检测到了近年该地区新鉴定出的流行重组形式（CRFs），包括CRF62_BC、CRF64_BC、CRF86_BC和CRF96_cpx。基因型在异性性传播和注射吸毒传播人群中的分布差异有统计学意义。发现耐药突变的比例为8.8%（13/147）。注射吸毒的HIV-1感染者中耐药株的比例（25.0%，8/32），高于异性性传播的HIV-1感染者（4.6%，5/109）（χ2=10.166，P=0.002）。结论 2017年德宏州初始ART的HIV-1感染者中病毒基因型高度复杂，HIV-1耐药株的流行达中度水平。 |
| English Abstract: |
| Objective To understand the distribution of HIV-1 genotypes and the status of drug resistance among people living with HIV who had prepared to initiate antiretroviral therapy (ART) in Dehong Dai and Jingpo autonomous prefecture (Dehong). Methods A total of 170 adults with HIV were recruited in Dehong from January to June 2017, before initiating ART. HIV-1 pol genes were amplified and used to analyze the HIV-1 genotypes and drug resistance. Results A total of 147 samples were successfully sequenced. Based on the phylogenetic analysis, 12 HIV-1 genotypes were found among the subjects, including three predominant genotypes such as subtype C (29.9%, 44/147), unique recombinant forms (URFs) (27.2%, 40/147) and CRF01_AE (19.7%, 29/147). Circulating recombinant forms (CRFs) which were newly identified in this area in recent years were also found among these subjects, including CRF62_BC, CRF64_BC, CRF86_BC and CRF96_cpx. The distribution of HIV-1 genotypes between heterosexual transmission or intravenous drug use, showed statistical difference. Surveillance drug resistance mutations (SDRMs) were found among 8.8% (13/147) of the subjects. Proportion of drug resistant strains among injecting drug users (25.0%, 8/32) was higher than that among those heterosexual transmitted individuals (4.6%, 5/109, χ2=10.166, P=0.002). Conclusions Among people living with HIV-1 who had prepared to initiate ART, their HIV-1 genetics were highly complicated, with moderate prevalence rate of HIV-1 drug-resistant strains. |
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