睡眠打鼾与浙江省成年人高血压患病关联的研究

谢开婿; 王春梅; 陈玲琍; 曹元; 沈盾; 胡如英; 王浩; 钟节鸣; 俞敏

Abstract

谢开婿,王春梅,陈玲琍,曹元,沈盾,胡如英,王浩,钟节鸣,俞敏.睡眠打鼾与浙江省成年人高血压患病关联的研究[J].Chinese journal of Epidemiology,2020,41(5):722-726

睡眠打鼾与浙江省成年人高血压患病关联的研究

Association between snoring and hypertension among Zhejiang adults in a cross sectional study

Received:August 14, 2019

DOI：10.3760/cma.j.cn112338-20190814-00596

KeyWord: 打鼾高血压成年人横断面研究

English Key Word: Snoring Hypertension Adults Cross-sectional study

FundProject:国家重点研发计划（2016YFC0900500，2016YFC0900501，2016YFC0900502，2016YFC0900504）；中国香港Kadoorie Charitable基金；英国Wellcome Trust （202922/Z/16/Z，088158/Z/09/Z，104085/Z/14/Z）

Author Name	Affiliation	E-mail
Xie Kaixu	Department of Non-communicable Diseases Control and Prevention, Tongxiang City Center for Disease Control and Prevention, Tongxiang 314500, China
Wang Chunmei	Department of Non-communicable Diseases Control and Prevention, Tongxiang City Center for Disease Control and Prevention, Tongxiang 314500, China
Chen Lingli	Department of Non-communicable Diseases Control and Prevention, Tongxiang City Center for Disease Control and Prevention, Tongxiang 314500, China
Cao Yuan	Department of Non-communicable Diseases Control and Prevention, Tongxiang City Center for Disease Control and Prevention, Tongxiang 314500, China
Shen Dun	Department of Non-communicable Diseases Control and Prevention, Tongxiang City Center for Disease Control and Prevention, Tongxiang 314500, China
Hu Ruying	Department of Non-communicable Diseases Control and Prevention, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China
Wang Hao	Department of Non-communicable Diseases Control and Prevention, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China	wanghao7710@163.com
Zhong Jieming	Department of Non-communicable Diseases Control and Prevention, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China
Yu Min	Department of Non-communicable Diseases Control and Prevention, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China

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Abstract:

目的探讨打鼾与成年人高血压患病的关联。方法对中国慢性病前瞻性研究浙江省桐乡市基线数据进行横断面分析，剔除调查时自报曾被医生诊断患有恶性肿瘤、心脏病和脑卒中患者后，纳入分析30~79岁者共56 728人。采用logistic回归模型分析打鼾与高血压患病之间的OR值。结果调查对象中，经常打鼾、偶尔打鼾和不打鼾的比例分别为24.55%、23.94%和51.51%。男性中的比例分别为32.40%、26.55%和41.05%；女性中的比例分别为19.00%、22.08%和58.92%。调整人口社会学因素、行为生活方式、睡眠时间、BMI和腰围等危险因素后，高血压患病风险随打鼾频率的增加而增加（P<0.001）。与不打鼾者相比，经常打鼾者和偶尔打鼾者高血压患病的OR值（95% CI）分别为1.17（1.12~1.23）和1.12（1.07~1.18）。与不打鼾者相比，经常打鼾与高血压的关联在男性和女性、已绝经女性和未绝经女性、中心性肥胖和非中心性肥胖人群中的关联差异有统计学意义。结论睡眠时打鼾与高血压患病存在关联。打鼾对高血压的影响在女性、中心性肥胖者和未绝经者中更明显。

English Abstract:

Objective To explore the association between snoring and prevalent hypertension among adults in Zhejiang with a cross-sectional study. Methods After excluding participants with self-reported, physician-diagnosed heart diseases, stroke and cancer at baseline study, 56 728 participants aged 30-79 in the China Kadoorie Biobank study from Tongxiang, Zhejiang were included for the final analysis. Three multivariable logistic regression models were used to estimate the ORs for the associations of snoring with prevalent hypertension. Results The proportion of participants who snored frequently, snored sometimes, and never snored were 24.55%, 23.94%, and 51.51%, respectively. The corresponding figures of males were 32.40%, 26.55%, and 41.05%, respectively. The corresponding figures of females were 19.00%, 22.08%, and 58.92%, respectively (P<0.001). After adjusted socio-demographic factors, behavioral lifestyle, BMI, waist circumference, and sleep duration etc., in comparison with participants who never snored, the odds ratios (95%CI) of hypertension for those who snored frequently and snored sometimes were 1.17 (1.12-1.23) and 1.12 (1.07-1.18), respectively. The effects of snoring on hypertension were statistically significantly different between women and men, participants who were central obese and those who were not, and between premenopausal and post-menopausal women. Conclusion Snoring was associated positively with hypertension among adults. The effect of snoring on prevalent hypertension were obvious, especially among people, being female, being central obese, and being premenopausal.

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