| 尤柳青,高垲,李其龙,杨金华,李佳昱,章晓聪,唐梦龄,王建炳,陈坤,金明娟.基于人群筛查的生活方式相关因素与结直肠腺瘤的关系研究[J].Chinese journal of Epidemiology,2020,41(10):1649-1654 |
| 基于人群筛查的生活方式相关因素与结直肠腺瘤的关系研究 |
| Association between lifestyle-related factors and colorectal adenoma |
| Received:April 14, 2020 |
| DOI：10.3760/cma.j.cn112338-20200414-00572 |
| KeyWord: 结直肠腺瘤 生活方式相关因素 阿司匹林 |
| English Key Word: Colorectal adenoma Lifestyle-related factor Aspirin |
| FundProject:国家自然科学基金（81973124，81673262）；国家重点基础研究发展计划（973计划）（2015CB554003） |
| Author Name | Affiliation | E-mail | | You Liuqing | Department of Epidemiology and Biostatistics, Zhejiang University School of Public Health, Hangzhou 310058, China | | | Gao Kai | Department of Epidemiology and Biostatistics, Zhejiang University School of Public Health, Hangzhou 310058, China | | | Li Qilong | Jiashan Institute of Cancer Prevention and Treatment of Zhejiang Province, Jiaxing 314100, China | | | Yang Jinhua | Jiashan Institute of Cancer Prevention and Treatment of Zhejiang Province, Jiaxing 314100, China | | | Li Jiayu | Department of Epidemiology and Biostatistics, Zhejiang University School of Public Health, Hangzhou 310058, China | | | Zhang Xiaocong | Department of Epidemiology and Biostatistics, Zhejiang University School of Public Health, Hangzhou 310058, China | | | Tang Mengling | Department of Epidemiology and Biostatistics, Zhejiang University School of Public Health, Hangzhou 310058, China | | | Wang Jianbing | Department of Epidemiology and Biostatistics, Zhejiang University School of Public Health, Hangzhou 310058, China | | | Chen Kun | Department of Epidemiology and Biostatistics, Zhejiang University School of Public Health, Hangzhou 310058, China | | | Jin Mingjuan | Department of Epidemiology and Biostatistics, Zhejiang University School of Public Health, Hangzhou 310058, China | jinmj@zju.edu.cn |
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| Abstract: |
| 目的 探讨生活方式相关因素与结直肠腺瘤之间的关系。方法 基于浙江省嘉善县结直肠癌早诊早治筛查项目，收集2012年8月至2018年3月初筛阳性的结直肠癌高危人群的问卷信息和结直肠镜检查结果。根据肠镜检查结果，纳入11 232例无病变健康对照和3 895例结直肠腺瘤患者，采用多因素logistic回归模型分析各生活方式相关因素与结直肠腺瘤之间的联系。结果 调整潜在的混杂因素后，吸烟、饮酒、肥胖与结直肠腺瘤患病风险呈正相关，OR值（95% CI）分别为1.38（1.24~1.54）、1.37（1.24~1.51）和1.38（1.20~1.59）；规律服用阿司匹林与结直肠腺瘤患病风险呈负相关，OR值（95% CI）为0.65（0.53~0.80）。以性别和年龄为分层因素的分析发现，吸烟、饮酒与结直肠腺瘤的关联效应仅在男性中具有统计学意义，规律服用阿司匹林与结直肠腺瘤的关联效应则在老年人（≥60岁）中更强。结论 吸烟、饮酒、规律服用阿司匹林、肥胖等生活方式相关因素与结直肠腺瘤患病风险相关。 |
| English Abstract: |
| Objective To explore the association between lifestyle-related factors and colorectal adenoma. Methods Based on the Screening Project of Early Diagnosis and Treatment of Colorectal Cancer in Jiashan county Zhejiang province, from August 2012 to March 2018, information gathered through records on questionnaire and colonoscopic diagnosis were collected from participants with positive results during the primary screening stage. According to the findings of colonoscopy, 11 232 controls without any colorectal diseases and 3 895 cases with colorectal adenoma were included in the study. Multivariate logistic regression models were used to analyze the association between lifestyle-related factors and colorectal adenoma. Results After adjusting for possible confounding factors, results from multivariate logistic regression analysis showed that smoking, alcohol drinking and obesity were positively related to the risk of colorectal adenoma, with ORs (95% CIs) as 1.38 (1.24-1.54), 1.37 (1.24-1.51) and 1.38 (1.20-1.59) respectively. However, regular aspirin intake was negatively related with the risk of colorectal adenoma (OR=0.65, 95% CI: 0.53-0.80). After stratified by sex and age, data showed that the associations between smoking, alcohol drinking and colorectal adenoma were statistically significant in males, and the association between regular aspirin intake and colorectal adenoma was also statistically significant in older participants (aged 60 years and older). Conclusion Smoking, alcohol drinking, regular aspirin intake and obesity were associated with colorectal adenoma. |
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