| 韩珂,王盛书,贾王平,杨姗姗,曹文哲,赵亚力,朱乔,甯超学,刘淼,何耀.海南百岁老人血清白蛋白水平与健康相关生活质量的关联性研究[J].Chinese journal of Epidemiology,2021,42(1):88-93 |
| 海南百岁老人血清白蛋白水平与健康相关生活质量的关联性研究 |
| Association between serum albumin level and health-related quality of life in Hainan centenarians: a cross-sectional study |
| Received:April 24, 2020 |
| DOI：10.3760/cma.j.cn112338-20200424-00637 |
| KeyWord: 血清白蛋白 百岁老人 海南 健康相关生活质量 横断面研究 |
| English Key Word: Serum albumin Centenarian Hainan Health-related quality of life Cross-sectional study |
| FundProject:国家自然科学基金（81773502，81703308，81703285）；北京市科技新星计划（Z181100006218085）；国家老年疾病临床医学研究中心开放课题（NCRCG-PLAGH-2017017）；国家重点研发计划（2018YFC2000400）；解放军总医院医疗大数据研发项目（MBD2018030） |
| Author Name | Affiliation | E-mail | | Han Ke | Institute of Geriatrics, Beijing Key Laboratory of Research on Aging and Related Diseases, State Key Laboratory of Kidney Disease, National Clinical Research Center for Geriatrics Diseases, Chinese People's Liberation Army General Hospital, Beijing 100853, China | | | Wang Shengshu | Institute of Geriatrics, Beijing Key Laboratory of Research on Aging and Related Diseases, State Key Laboratory of Kidney Disease, National Clinical Research Center for Geriatrics Diseases, Chinese People's Liberation Army General Hospital, Beijing 100853, China | | | Jia Wangping | Institute of Geriatrics, Beijing Key Laboratory of Research on Aging and Related Diseases, State Key Laboratory of Kidney Disease, National Clinical Research Center for Geriatrics Diseases, Chinese People's Liberation Army General Hospital, Beijing 100853, China | | | Yang Shanshan | Institute of Geriatrics, Beijing Key Laboratory of Research on Aging and Related Diseases, State Key Laboratory of Kidney Disease, National Clinical Research Center for Geriatrics Diseases, Chinese People's Liberation Army General Hospital, Beijing 100853, China | | | Cao Wenzhe | Institute of Geriatrics, Beijing Key Laboratory of Research on Aging and Related Diseases, State Key Laboratory of Kidney Disease, National Clinical Research Center for Geriatrics Diseases, Chinese People's Liberation Army General Hospital, Beijing 100853, China | | | Zhao Yali | Central Laboratory of Hainan Hospital, Chinese People's Liberation Army General Hospital, Sanya 572013, China | | | Zhu Qiao | Central Laboratory of Hainan Hospital, Chinese People's Liberation Army General Hospital, Sanya 572013, China | | | Ning Chaoxue | Central Laboratory of Hainan Hospital, Chinese People's Liberation Army General Hospital, Sanya 572013, China | | | Liu Miao | Department of Statistics and Epidemiology, Graduate School, Chinese People's Liberation Army General Hospital, Beijing 100853, China | liumiaolmbxb@163.com | | He Yao | Institute of Geriatrics, Beijing Key Laboratory of Research on Aging and Related Diseases, State Key Laboratory of Kidney Disease, National Clinical Research Center for Geriatrics Diseases, Chinese People's Liberation Army General Hospital, Beijing 100853, China | |
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| Abstract: |
| 目的 探讨中国海南百岁老人血清白蛋白水平与健康相关生活质量的关系。方法 本研究数据来自中国海南百岁老人队列研究2014-2016年横断面数据集，共纳入1 002名百岁老人进行问卷调查、体格检查和生物学标本检测。采用EQ-5D-VAS量表测量健康相关生活质量，采用多重线性回归和多元logistic回归分析血清白蛋白和健康相关生活质量的关联。结果 血清白蛋白与视觉模拟量表得分之间存在正向线性关系，在完全调整模型中标准化β值为0.156（P<0.001）。在多元logistic回归分析中，低白蛋白水平组的健康相关生活质量受损的风险是高白蛋白水平组的2.369倍（95%CI：1.424~3.939）；性别分层分析显示，男性百岁老人中OR=4.406（95%CI：1.537~12.631），女性百岁老人中OR=2.035（95%CI：1.125~3.680）。结论 海南百岁老人中较低水平的血清白蛋白水平与健康相关生活质量下降有关。 |
| English Abstract: |
| Objective To investigate the association between serum albumin levels and health-related quality of life in centenarians in Hainan province, China. Methods We conducted a full sample centenarian cohort study in a community population in Hainan from 2014 to 2016, which included 1 002 centenarians for questionnaire surveys, physical examinations and biological tests. The EQ-5D-VAS scale was used to evaluate health-related quality of life, and multiple linear regression and multiple logistic regression analyses were used to analyze the association between serum albumin levels and health-related quality of life. Results There was a positive linear relationship between serum albumin levels and EQ-5D/VAS score. The normalized β values in the fully adjusted model was 0.156 (P<0.001). In the multivariate logistic regression analysis, after fully adjusting the covariates, the risk of health related life quality impairment in the lower albumin group was 2.369 times(95%CI:1.424-3.939) than that in the higher albumin group. Gender stratified analyses showed that the OR was 4.406 (95%CI:1.537-12.631) in male centenarians and 2.035 (95%CI:1.125-3.680) in female centenarians. Conclusion Lower serum albumin level was associated with impaired health-related quality of life in centenarians in Hainan. |
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