| 贾王平,杨姗姗,王盛书,曹文哲,韩珂,刘淼,赵亚力,朱乔,甯超学,何耀.海南高龄及百岁老人贫血相关检测指标的参考值范围探讨[J].Chinese journal of Epidemiology,2021,42(1):94-98 |
| 海南高龄及百岁老人贫血相关检测指标的参考值范围探讨 |
| Reference intervals for anemia-related routine blood test indicators in Hainan oldest-old and Hainan centenarians |
| Received:April 24, 2020 |
| DOI：10.3760/cma.j.cn112338-20200424-00640 |
| KeyWord: 贫血 高龄老人 百岁老人 参考值范围 |
| English Key Word: Anemia Oldest-old Centenarian Reference interval |
| FundProject:国家自然科学基金（81773502，81703308，81703285）；北京市科技新星计划（Z181100006218085）；国家老年疾病临床医学研究中心开放课题（NCRCG-PLAGH-2017017）；国家重点研发计划（2018YFC2000400）；解放军总医院医疗大数据研发项目（MBD2018030） |
| Author Name | Affiliation | E-mail | | Jia Wangping | Institute of Geriatrics, Beijing Key Laboratory of Research on Aging and Related Diseases, State Key Laboratory of Kidney Disease, National Clinical Research Center for Geriatrics Diseases, Chinese People's Liberation Army General Hospital, Beijing 100853, China | | | Yang Shanshan | Institute of Geriatrics, Beijing Key Laboratory of Research on Aging and Related Diseases, State Key Laboratory of Kidney Disease, National Clinical Research Center for Geriatrics Diseases, Chinese People's Liberation Army General Hospital, Beijing 100853, China
Department of Disease Control and Prevention, the First Medical Center, Chinese People's Liberation Army General Hospital, Beijing 100853, China | | | Wang Shengshu | Institute of Geriatrics, Beijing Key Laboratory of Research on Aging and Related Diseases, State Key Laboratory of Kidney Disease, National Clinical Research Center for Geriatrics Diseases, Chinese People's Liberation Army General Hospital, Beijing 100853, China | | | Cao Wenzhe | Institute of Geriatrics, Beijing Key Laboratory of Research on Aging and Related Diseases, State Key Laboratory of Kidney Disease, National Clinical Research Center for Geriatrics Diseases, Chinese People's Liberation Army General Hospital, Beijing 100853, China | | | Han Ke | Institute of Geriatrics, Beijing Key Laboratory of Research on Aging and Related Diseases, State Key Laboratory of Kidney Disease, National Clinical Research Center for Geriatrics Diseases, Chinese People's Liberation Army General Hospital, Beijing 100853, China | | | Liu Miao | Institute of Geriatrics, Beijing Key Laboratory of Research on Aging and Related Diseases, State Key Laboratory of Kidney Disease, National Clinical Research Center for Geriatrics Diseases, Chinese People's Liberation Army General Hospital, Beijing 100853, China
Department of Statistics and Epidemiology, Graduate School, Chinese People's Liberation Army General Hospital, Beijing 100853, China | | | Zhao Yali | Central Laboratory of Hainan Hospital, Chinese People's Liberation Army General Hospital, Sanya 572013, China | | | Zhu Qiao | Central Laboratory of Hainan Hospital, Chinese People's Liberation Army General Hospital, Sanya 572013, China | | | Ning Chaoxue | Central Laboratory of Hainan Hospital, Chinese People's Liberation Army General Hospital, Sanya 572013, China | | | He Yao | Institute of Geriatrics, Beijing Key Laboratory of Research on Aging and Related Diseases, State Key Laboratory of Kidney Disease, National Clinical Research Center for Geriatrics Diseases, Chinese People's Liberation Army General Hospital, Beijing 100853, China | yhe301@sina.com |
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| Abstract: |
| 目的 探讨我国海南高龄及百岁老人贫血相关检测指标的参考值范围。方法 数据来源于中国海南高龄及百岁老人队列研究数据库。按照标准化流程，进行问卷调查，体格检查和血液样本分析。对血红蛋白浓度、红细胞计数及血细胞比容3项指标的数据进行统计分析，采用百分位数法统计双侧95%界限，建立医学参考值范围。结果 共纳入767名高龄老人（男性312名，占40.7%）与715名百岁老人（男性137名，占19.2%）。血红蛋白的参考值范围在高龄老人男性和女性中分别为89.1~173.5 g/L与94.4~146.0 g/L；在百岁老人男性与女性中分别为68.4~145.6 g/L与81.0~140.0 g/L。结论 本研究首次提供了海南高龄及百岁老人贫血相关检测指标的参考值范围，且低于目前成年人的参考标准值范围。 |
| English Abstract: |
| Objective To investigate reference intervals for anemia-related routine blood test indicators in Hainan oldest-old and Hainan centenarians. Methods A cross-sectional data set of China Hainan Centenarians Cohort Study (CHCCS) was used. Household interview, physical examinations, and blood sample analysis were conducted in accordance with standardized procedures. The hemoglobin level, red blood cell count, and hematocrit were analyzed with automatic biochemical analyzer and the reference intervals were determined following CLSI C28-A3 guidelines using a non-parametric method. Results A total of 715 centenarians, including 137 males (19.2%), and 767 long-lived individuals aged ≥ 80 years, including 312 males (40.7%), were surveyed. The reference interval of hemoglobin level was 89.1-173.5 g/L in males and 94.4-146.0 g/L in females, respectively, in long-lived individual group. The reference interval of hemoglobin level was 68.4-145.6 g/L in males and 81.0-140.0 g/L in females, respectively, in centenarian group. Conclusion The reference intervals of hemoglobin level, red blood cell count, and hematocrit were set for the first time for the oldest-old and centenarians in Hainan, which was lower than that currently used in adults. |
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