| 董爽,姚添,邵志宏,武媛婷,刘渊,武俊华,薛通川,冯永亮,王素萍.太原市美沙酮维持治疗患者HCV感染相关因素及交互作用分析[J].Chinese journal of Epidemiology,2021,42(4):677-682 |
| 太原市美沙酮维持治疗患者HCV感染相关因素及交互作用分析 |
| Related factors and interaction on hepatitis C virus infection in patients receiving methadone maintenance treatment in Taiyuan |
| Received:October 28, 2020 |
| DOI：10.3760/cma.j.cn112338-20201028-01289 |
| KeyWord: 美沙酮维持治疗 丙型肝炎病毒 感染 相关因素 交互作用 |
| English Key Word: Methadone maintenance treatment Hepatitis C virus Infection Related factor Interaction |
| FundProject:国家科技重大专项（2018ZX10721202，2012ZXl0002001） |
| Author Name | Affiliation | E-mail | | Dong Shuang | Department of Epidemiology, Shanxi Medical University, Taiyuan 030001, China
Center of Clinical Epidemiology and Evidence Based Medicine, Shanxi Medical University, Taiyuan 030001, China | | | Yao Tian | Department of Epidemiology, Shanxi Medical University, Taiyuan 030001, China
Center of Clinical Epidemiology and Evidence Based Medicine, Shanxi Medical University, Taiyuan 030001, China | | | Shao Zhihong | Department of Epidemiology, Shanxi Medical University, Taiyuan 030001, China
Center of Clinical Epidemiology and Evidence Based Medicine, Shanxi Medical University, Taiyuan 030001, China | | | Wu Yuanting | Department of Epidemiology, Shanxi Medical University, Taiyuan 030001, China
Center of Clinical Epidemiology and Evidence Based Medicine, Shanxi Medical University, Taiyuan 030001, China | | | Liu Yuan | Methadone Maintenance Treatment Clinic, Compulsory Isolation Drug Rehabilitation Center of Shanxi Province, Taiyuan 030001, China | | | Wu Junhua | Methadone Maintenance Treatment Clinic 109 Hospital of Shanxi Province, Taiyuan 030001, China | | | Xue Tongchuan | Methadone Maintenance Treatment Clinic, Xinghualing Central Hospital of Shanxi Province, Taiyuan 030000, China | | | Feng Yongliang | Department of Epidemiology, Shanxi Medical University, Taiyuan 030001, China
Center of Clinical Epidemiology and Evidence Based Medicine, Shanxi Medical University, Taiyuan 030001, China | fengyongliang048@163.com | | Wang Suping | Department of Epidemiology, Shanxi Medical University, Taiyuan 030001, China
Center of Clinical Epidemiology and Evidence Based Medicine, Shanxi Medical University, Taiyuan 030001, China | spwang88@163.com |
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| Abstract: |
| 目的 分析太原市美沙酮维持治疗（MMT）患者HCV感染状况及其感染相关因素与交互作用。方法 2019年4-6月对太原市3所MMT门诊正在接受治疗的MMT患者，采用面对面问卷调查收集其一般人口学特征、吸毒情况、MMT情况、性行为、健康状况等，通过病历资料查阅MMT患者HCV检测结果，使用EpiData 3.1软件双录入数据，使用SAS 9.4软件进行统计学分析，用χ2检验进行HCV感染的单因素分析、logistic回归模型进行多因素和交互作用分析。结果 MMT患者846例中，男女性别比7.21：1（743：103），HCV感染率为12.53%（106/846）。控制混杂因素后，女性（OR=1.936，95%CI：1.023~3.662）、性伴有吸毒史（OR=2.073，95%CI：1.110~3.871）和注射吸毒者（OR=7.737，95%CI：4.614~12.973）的感染HCV风险较高。交互作用结果显示，女性、性伴有吸毒史者及注射吸毒者之间存在相乘交互作用。结论 太原市MMT患者中，女性、性伴有吸毒史者、注射吸毒者HCV感染的风险较高，女性与性伴有吸毒史者、女性与注射吸毒者、性伴有吸毒史者与注射吸毒者对HCV感染的发生存在相乘交互作用。 |
| English Abstract: |
| Objective To explore the prevalence of hepatitis C virus (HCV) infection, influence factors and interaction on HCV infection in patients receiving methadone maintenance treatment (MMT) in Taiyuan.Methods Between April-June 2019, three MMT clinics in Taiyuan were selected to conduct a face-to-face questionnaire survey among MMT patients to collect the information about their socio-demographic characteristics, drug use, MMT, sexual behavior and health status. Software EpiData 3.1 was used for real-time double entry to establish the database. Software SAS 9.4 was used to analyze the data, and χ2 test was used for univariate analysis and logistic regression model was used for multivariate and interaction analyses. Results A total of 903 subjects were surveyed among MMT patients, the male to female ratio of was 7.21:1(743:103), and the rate of HCV infection was 12.53% (106/846). After adjusting for the confounding factors, being women (OR=1.936, 95%CI:1.023-3.662), having sex with drug users (OR=2.073, 95%CI:1.110-3.871) and injection drug use (OR=7.737, 95%CI:4.614-12.973) might be the risk factors for HCV infection in patients receiving MMT. The results showed that there were multiplicative interactions among women, having sex with drug user and injection drug use on HCV infection.Conclusions Being women, having sex with drug user and injection drug use were associated with higher risk for HCV infection in patients receiving MMT in Taiyuan. There were multiplication interactions between being women and having sex with drug user, being female and injection drug use, and having sex with drug use and injection drug use on HCV infection. |
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