| 郑可,高文静,吕筠,余灿清,王胜锋,黄涛,孙点剑一,廖春晓,庞元捷,逄增昌,俞敏,汪华,吴先萍,董忠,吴凡,江国虹,王晓节,刘彧,邓健,陆林,曹卫华,李立明.中国双生子人群2型糖尿病分布特征[J].Chinese journal of Epidemiology,2022,43(5):634-640 |
| 中国双生子人群2型糖尿病分布特征 |
| A descriptive analysis on type 2 diabetes in twins in China |
| Received:July 05, 2021 |
| DOI：10.3760/cma.j.cn112338-20210705-00520 |
| KeyWord: 糖尿病,2型 双生子研究 同病率 现况研究 |
| English Key Word: Type 2 diabetes Twin study Concordance rate Cross-sectional study |
| FundProject:公益性行业科研专项(201502006,201002007) |
| Author Name | Affiliation | E-mail | | Zheng Ke | Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China | | | Gao Wenjing | Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China | pkuepigwj@126.com | | Lyu Jun | Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China | | | Yu Canqing | Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China | | | Wang Shengfeng | Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China | | | Huang Tao | Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China | | | Sun Dianjianyi | Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China | | | Liao Chunxiao | Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China | | | Pang Yuanjie | Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China | | | Pang Zengchang | Qingdao Municipal Center for Disease Control and Prevention, Qingdao 266033, China | | | Yu Min | Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China | | | Wang Hua | Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China | | | Wu Xianping | Sichuan Provincial Center for Disease Control and Prevention, Chengdu 610041, China | | | Dong Zhong | Beijing Center for Disease Prevention and Control, Beijing 100013, China | | | Wu Fan | Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, China | | | Jiang Guohong | Tianjin Centers for Disease Control and Prevention, Tianjin 300011, China | | | Wang Xiaojie | Qinghai Center for Diseases Prevention and Control, Xining 810007, China | | | Liu Yu | Heilongjiang Provincial Center for Disease Control and Prevention, Harbin 150090, China | | | Deng Jian | Handan Center for Disease Control and Prevention, Handan 056001, China | | | Lu Lin | Yunnan Center for Disease Control and Prevention, Kunming 650034, China | | | Cao Weihua | Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China | | | Li Liming | Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China | |
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| Abstract: |
| 目的 描述中国双生子登记系统（CNTR）双生子的2型糖尿病分布特征，为揭示遗传和环境因素对2型糖尿病的影响提供线索和依据。方法 CNTR 2010-2018年项目登记的所有双生子中，纳入≥30岁且有完整登记信息的18 855对双生子作为研究对象。采用随机效应模型描述2型糖尿病的人群、地区分布特征以及对内一致性的分布。结果 研究对象年龄（42.8±10.2）岁，同卵双生子（MZ）10 339对，异卵双生子（DZ）8 516对。全人群中2型糖尿病报告患病率为2.2%，MZ和DZ报告患病率差异无统计学意义。双生子对内分析发现2型糖尿病MZ同病率为38.2%，DZ为16.0%，差异有统计学意义（P<0.001），在不同性别、年龄和地区中MZ同病率均大于DZ（P<0.05）。进一步分层分析，在北方，仅在<60岁人群中发现MZ同病率大于DZ（P<0.05）；而南方，≥60岁男性MZ同病率也大于DZ（P<0.05）。结论 本研究的双生子人群2型糖尿病报告患病率低于一般人群，在不同性别、年龄和地区中均提示遗传因素在2型糖尿病中起作用，但其作用大小可能不尽相同。 |
| English Abstract: |
| Objective To describe the distribution characteristics of type 2 diabetes in twins in Chinese National Twin Registry (CNTR), provide clues and evidence for revealing the influence of genetic and environmental factors for type 2 diabetes. Methods Of all twins registered in the CNTR during 2010-2018, a total 18 855 twin pairs aged ≥30 years with complete registration information were included in the analysis. The random effect model was used to describe the population and area distribution characteristics and concordance of type 2 diabetes in twin pairs. Results The mean age of the subjects was (42.8±10.2) years, the study subjects included 10 339 monozygotic (MZ) twin pairs and 8 516 dizygotic (DZ) twin pairs. The self-reported prevalence rate of type 2 diabetes was 2.2% in total population and there was no sighificant difference between MZ and DZ. Intra-twin pairs analysis showed that the concordance rate of type 2 diabetes was 38.2% in MZ twin pairs, and 16.0% in DZ twin pairs, the difference was statistically significant (P<0.001). The concordance rate of type 2 diabetes in MZ twin parts was higher than that in DZ twin pairs in both men and women, in different age groups and in different areas (P<0.05). Further stratified analysis showed that in northern China, only MZ twin pairs less than 60 years old were found to have a higher concordance rate of type 2 diabetes compared with DZ twin pairs (P<0.05). In southern China, the co-prevalence rate in male MZ twin pairs aged ≥60 years was still higher than that in DZ twin pairs (P<0.05). Conclusion The twin pairs in this study had a lower self-reported prevalence of type 2 diabetes than the general population. The study results suggested that genetic factors play a role in type 2 diabetes prevalence in both men and women, in different age groups and in different areas, however, the effect might vary. |
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