| 杨君婷,刘志科,詹思延.孕妇新型冠状病毒肺炎及疫苗的流行病学研究进展[J].Chinese journal of Epidemiology,2022,43(8):1215-1221 |
| 孕妇新型冠状病毒肺炎及疫苗的流行病学研究进展 |
| Progress in epidemiological research of 2019-nCoV infection and COVID-19 vaccination in pregnancy |
| Received:March 23, 2022 |
| DOI：10.3760/cma.j.cn112338-20220323-00217 |
| KeyWord: 新型冠状病毒肺炎 孕妇 新型冠状病毒变异株 疫苗 真实世界 |
| English Key Word: COVID-19 Pregnancy 2019-nCoV variant Vaccine Real-world study |
| FundProject:国家自然科学基金（91846303，81973146）；中国中医药循证医学中心业务研究室主任专项（2020YJSZX-2） |
| Author Name | Affiliation | E-mail | | Yang Junting | Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China
Key Laboratory for Research and Evaluation of Pharmacovigilance, National Medical Products Administration, Peking University, Beijing 100191, China | | | Liu Zhike | Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China
Key Laboratory for Research and Evaluation of Pharmacovigilance, National Medical Products Administration, Peking University, Beijing 100191, China | | | Zhan Siyan | Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China
Key Laboratory for Research and Evaluation of Pharmacovigilance, National Medical Products Administration, Peking University, Beijing 100191, China
Research Center of Clinical Epidemiology, Peking University Third Hospital, Beijing 100191, China
Center for Intelligent Public Health, Institute for Artificial Intelligence, Peking University, Beijing 100871, China | siyan-zhan@bjmu.edu.cn |
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| Abstract: |
| 新型冠状病毒肺炎（COVID-19）是一种由新型冠状病毒（新冠病毒）引起的急性呼吸道传染性疾病。由于妊娠期间的生理变化，孕妇易感COVID-19，尤其是新冠病毒变异株流行期间，孕妇不良妊娠结局的发生风险可能更高。目前尚缺乏孕妇接种新冠病毒疫苗（新冠疫苗）的随机临床试验证据，各国关于孕妇接种新冠疫苗的推荐存在差异，这给孕妇COVID-19的防控带来了一定挑战。本文回顾了国内外妊娠期感染新冠病毒的重要研究进展，论述了妊娠期患COVID-19对孕妇、胎儿及婴儿的危害，以及真实世界研究中妊娠期接种新冠疫苗的有效性和安全性等，以期为今后开展孕妇相关研究，制定防控措施提供参考。 |
| English Abstract: |
| Coronavirus disease 2019 (COVID-19) is an acute respiratory infectious disease caused by 2019-nCoV. Due to the physiological change in pregnancy, pregnant women are susceptible to COVID-19 and are at increased risk for adverse pregnancy outcomes, especially in the context of spread of novel variants. At present, less evidences have been obtained from randomized controlled trials on the effectiveness and safety of COVID-19 vaccine use in pregnant women, and the recommendations of COVID-19 vaccination for pregnant women vary with countries, posing challenge to the prevention and control of COVID-19 in pregnant women. This paper summarizes the progress in major research of 2019-nCoV infection in pregnancy conducted both at home and abroad, describes the harm of COVID-19 in pregnancy to pregnant women, fetuses and infants and introduces the effectiveness and safety of COVID-19 vaccination in pregnancy revealed by real world studies in order to provide reference for the related research and development of COVID-19 prevention and control strategies in pregnant women. |
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