| 毋之钰,高文静,曹卫华,吕筠,余灿清,王胜锋,黄涛,孙点剑一,廖春晓,庞元捷,逄增昌,俞敏,汪华,吴先萍,董忠,吴凡,江国虹,王晓节,刘彧,邓健,陆林,李立明.中国成年双生子饮茶行为分布特征[J].Chinese journal of Epidemiology,2022,43(8):1241-1248 |
| 中国成年双生子饮茶行为分布特征 |
| A descriptive analysis of tea consumption in adult twins in China |
| Received:December 10, 2021 |
| DOI：10.3760/cma.j.cn112338-20211210-00964 |
| KeyWord: 饮茶 双生子 遗传 环境 |
| English Key Word: Tea consumption Twins Genetic factor Environmental factor |
| FundProject:公益性行业科研专项（201502006，201002007）；国家自然科学基金（81973126，82073633） |
| Author Name | Affiliation | E-mail | | Wu Zhiyu | Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing 100191, China | | | Gao Wenjing | Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing 100191, China | pkuepigwj@126.com | | Cao Weihua | Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing 100191, China | | | Lyu Jun | Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing 100191, China | | | Yu Canqing | Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing 100191, China | | | Wang Shengfeng | Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing 100191, China | | | Huang Tao | Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing 100191, China | | | Sun Dianjianyi | Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing 100191, China | | | Liao Chunxiao | Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing 100191, China | | | Pang Yuanjie | Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing 100191, China | | | Pang Zengchang | Qingdao Center for Disease Control and Prevention, Qingdao 266033, China | | | Yu Min | Zhejiang Center for Disease Control and Prevention, Hangzhou 310051, China | | | Wang Hua | Jiangsu Center for Disease Control and Prevention, Nanjing 210009, China | | | Wu Xianping | Sichuan Center for Disease Control and Prevention, Chengdu 610041, China | | | Dong Zhong | Beijing Center for Disease Prevention and Control, Beijing 100013, China | | | Wu Fan | Shanghai Center for Disease Control and Prevention, Shanghai 200336, China | | | Jiang Guohong | Tianjin Center for Disease Control and Prevention, Tianjin 300011, China | | | Wang Xiaojie | Qinghai Center for Disease Control and Prevention, Xining 810007, China | | | Liu Yu | Heilongjiang Center for Disease Control and Prevention, Harbin 150090, China | | | Deng Jian | Handan Center for Disease Control and Prevention, Handan 056001, China | | | Lu Lin | Yunnan Center for Disease Control and Prevention, Kunming 650034, China | | | Li Liming | Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing 100191, China | |
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| Abstract: |
| 目的 描述中国双生子登记系统（CNTR）成年双生子饮茶行为的分布特征，探索饮茶行为在双生子人群中的分布规律，为探究遗传和环境因素对饮茶行为的影响提供线索。方法 样本选自2010-2018年在CNTR进行登记的双生子，纳入≥18岁且具有饮茶信息的双生子共25 264对进行分析，描述双生子中饮茶行为的人群、地区分布特征，以及不同卵型双生子饮茶行为一致率和对内饮茶量差异分布情况。结果 研究对象年龄（35.38±12.45）岁，每周饮茶者占比17.0%，饮茶量（3.36±2.44）杯/d。男性、50~59岁、南方、城镇、文化程度高、双生子中先出生的个体中每周饮茶者比例较高（P<0.05），未婚者中比例较低（P<0.001）。双生子对内分析发现同卵饮茶行为一致率均大于异卵，饮茶遗传度为13.45%（11.38%~15.51%），除女性亚组外，不同性别、年龄、地区间饮茶一致率差异有统计学意义（均P<0.05）；根据性别、年龄、地区分层后仅男性同卵一致率始终呈大于异卵趋势。同性别双生子对内饮茶量差异在男性中呈现同卵小于异卵的特征（P<0.05），而女性中差异不明显。结论 本研究双生子人群饮茶行为的分布存在人群和地区差异，饮茶行为主要受环境因素影响，遗传因素影响较弱，且遗传效应大小在不同性别、年龄、地区间不尽相同，性别可修饰这一遗传作用。 |
| English Abstract: |
| Objective To describe the distribution characteristics of tea consumption in adult twins recruited in the Chinese National Twin Registry (CNTR) and provide clues to genetic and environmental influences on tea consumption. Methods Enrolled in CNTR during 2010-2018, 25 264 twin pairs aged 18 years and above were included in subsequent analysis. Random effect models were used to estimate tea consumption in the population and regional distribution characteristics. The concordance rate of the behavior and difference in consumption volume of tea within pairs were also described. Results The mean age of all subjects was (35.38±12.45) years old. The weekly tea consumers accounted for 17.0%, with an average tea consumption of (3.36±2.44) cups per day. The proportion of weekly tea consumers was higher among males, 50-59 years old, southern, urban, educated, and the first-born in the twin pair (P<0.05), and lower among unmarried individuals (P<0.001). Within-pair analysis showed that the concordance rate of tea consumption of monozygotic (MZ) twins was higher than that of dizygotic (DZ) twins and the overall heritability of tea consumption was 13.45% (11.38%-15.51%). Stratified by the characteristics mentioned above, only in males, the concordance rate of MZ showed a tendency to be greater than that of DZ (all P<0.05). The differences in consumption volume of tea within twin pairs were minor in MZ among males (P<0.05), while the differences were not significant in female twins. Conclusion There were discrepancies in the distribution of tea consumption among twins of different demographic and regional characteristics. Tea consumption was mainly influenced by environmental factors and slightly influenced by genetic factors. The size of genetic factors varied with gender, age, and region, and gender was a potential modified factor. |
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