| 张合华,常青,吴琪俊,夏阳,高山砚,张旖骁,袁媛,姜晶,邱洪斌,李静,卢春明,纪超,徐昕,黄东辉,戴蕙旭,赵之滢,李行,李晓莹,秦晓松,刘彩刚,马晓宇,徐鑫蕊,姚达,喻慧心,赵玉虹.东北区域自然人群队列设计与实践[J].Chinese journal of Epidemiology,2023,44(1):21-27 |
| 东北区域自然人群队列设计与实践 |
| Design and practice of general population cohort study in northeastern China |
| Received:October 05, 2022 |
| DOI：10.3760/cma.j.cn112338-20221005-00858 |
| KeyWord: 东北 自然人群 前瞻性队列研究 |
| English Key Word: Northeastern China General population Prospective cohort study |
| FundProject:国家重点研发计划“精准医学研究”重点专项“东北区域自然人群队列研究”项目（2017YFC0907400）；辽宁省揭榜挂帅项目“代谢性疾病精准防诊治技术”（2021JH1/10400050）；辽宁省科技厅重点研发指导计划项目（2019JH8/10300005） |
| Author Name | Affiliation | E-mail | | Zhang Hehua | Clinical Research Center/Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang 110022, China
Liaoning Key Laboratory for Precision Medical Research of Major Chronic Disease, Benxi 117004, China | | | Chang Qing | Clinical Research Center/Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang 110022, China
Liaoning Key Laboratory for Precision Medical Research of Major Chronic Disease, Benxi 117004, China | | | Wu Qijun | Clinical Research Center/Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang 110022, China | | | Xia Yang | Clinical Research Center/Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang 110022, China | | | Gao Shanyan | Clinical Research Center/Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang 110022, China
Liaoning Key Laboratory for Precision Medical Research of Major Chronic Disease, Benxi 117004, China | | | Zhang Yixiao | Liaoning Key Laboratory for Precision Medical Research of Major Chronic Disease, Benxi 117004, China
Department of Urology Surgery, Shengjing Hospital of China Medical University, Shenyang 110004, China | | | Yuan Yuan | Department of Medical Oncology, the First Affiliated Hospital of China Medical University, Shenyang 110001, China | | | Jiang Jing | Department of Clinical Research, the First Affiliated Hospital of Jilin University, Changchun 130021, China | | | Qiu Hongbin | Department of Epidemiology and Health Statistics, School of Public Health, Jiamusi University, Jiamusi 154007, China | | | Li Jing | Department of Endocrine and Metabolic Diseases, the First Affiliated Hospital of China Medical University, Shenyang 110001, China | | | Lu Chunming | Liaoning Provincial Center for Disease Control and Prevention, Shenyang 110005, China | | | Ji Chao | Clinical Research Center/Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang 110022, China | | | Xu Xin | Clinical Research Center/Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang 110022, China | | | Huang Donghui | Clinical Research Center/Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang 110022, China | | | Dai Huixu | Clinical Research Center/Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang 110022, China | | | Zhao Zhiying | Clinical Research Center/Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang 110022, China | | | Li Xing | Clinical Research Center/Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang 110022, China | | | Li Xiaoying | Clinical Research Center/Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang 110022, China | | | Qin Xiaosong | Clinical Laboratory, Shengjing Hospital of China Medical University, Shenyang 110004, China | | | Liu Caigang | Department of Oncology, Shengjing Hospital of China Medical University, Shenyang 110004, China | | | Ma Xiaoyu | Clinical Research Center/Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang 110022, China | | | Xu Xinrui | Clinical Research Center/Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang 110022, China | | | Yao Da | Clinical Research Center/Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang 110022, China | | | Yu Huixin | Data Center, Shengjing Hospital of China Medical University, Shenyang 110004, China | | | Zhao Yuhong | Clinical Research Center/Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang 110022, China
Liaoning Key Laboratory for Precision Medical Research of Major Chronic Disease, Benxi 117004, China | zhaoyh@sj-hospital.org |
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| Abstract: |
| 2016年我国在国家重点研发计划“精准医学研究”重点专项中发布国家百万自然人群队列建设项目，建设七大区域自然人群队列。东北地区作为我国区域划分七大地区之一，气候特征显著、膳食习惯独特且人口老龄化严重，其慢性非传染性疾病负担居全国前列。因此，建立东北区域大型自然人群队列，系统探寻疾病发生和预后相关区域特色暴露因素，为建立东北地区疾病预防新策略、降低国家医疗负担、提升东北地区人口健康水平，具有重要意义。2018年7月，东北区域自然人群队列现场工作启动，现场工作内容主要包括对参与者进行问卷调查、体格检查，以及血、尿、粪便样本的采集和检测，截至目前，队列总计完成各年龄层共115 414人的基线数据收集工作。本文简要介绍了东北区域自然人群队列建设概况，为国内相关研究提供参考。 |
| English Abstract: |
| In 2016, a national one million general population cohort project was set up in China for the first time in "Precision Medicine Research" Key Project, National Key Research and Development Program of China, which consists of general population cohorts in seven areas in China. As one of the seven major areas in China, northeastern China has unique climate and specific dietary patterns, and population aging is serious in this area. And the burden of chronic and non-communicable diseases ranks tops in China. Therefore, it is of great significance to establish a large general population cohort in northeastern China to explore the area specific exposure factors related to pathogenesis and prognosis of chronic and non-communicable diseases, develop new prevention strategies to reduce the burden of the diseases and improve the population health in northeastern China. In July 2018, the general population cohort study in northeastern China was launched, the study includes questionnaire survey, health examination and blood, urine and stool sample collection and detection in recruited participants. By now, the cohort has covered all age groups, and the baseline data of 115 414 persons have been collected. This paper summarizes the design and practice of the general population cohort study in northeastern China to provide reference for related research in China. |
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