| 陈仕敏,王盛书,宋扬,刘少华,李雪航,李志强,李皓炜,李蓉蓉,王建华,杨姗姗,赵亚力,李靖,朱乔,甯超学,刘淼,何耀.海南百岁老人抑郁症状对死亡与寿命影响的前瞻性队列研究[J].Chinese journal of Epidemiology,2023,44(1):99-105 |
| 海南百岁老人抑郁症状对死亡与寿命影响的前瞻性队列研究 |
| Effect of depressive symptom on the death and longevity in Hainan centenarians: a prospective cohort study |
| Received:April 13, 2022 |
| DOI：10.3760/cma.j.cn112338-20220413-00288 |
| KeyWord: 百岁老人 抑郁 全因死亡 队列研究 |
| English Key Word: Centenarian Depression All-cause death Cohort study |
| FundProject:国家自然科学基金（82173589，82173590，81941021）；首都卫生发展科研专项（2022-2G-5031）；国家重点研发计划（2018YFC2000400） |
| Author Name | Affiliation | E-mail | | Chen Shimin | Institute of Geriatrics, Beijing Key Laboratory of Aging and Geriatrics, National Clinical Research Center for Geriatric Diseases, Second Medical Center, Chinese People's Liberation Army General Hospital, Beijing 100853, China | | | Wang Shengshu | Institute of Geriatrics, Beijing Key Laboratory of Aging and Geriatrics, National Clinical Research Center for Geriatric Diseases, Second Medical Center, Chinese People's Liberation Army General Hospital, Beijing 100853, China
Department of Healthcare, Agency for Offices Administration, Central Military Commission, People's Republic of China, Beijing 100082, China | | | Song Yang | Institute of Geriatrics, Beijing Key Laboratory of Aging and Geriatrics, National Clinical Research Center for Geriatric Diseases, Second Medical Center, Chinese People's Liberation Army General Hospital, Beijing 100853, China
Health Corps, Special Combat Detachment of Xinjiang Armed Police Crops, Aksu 843000, China | | | Liu Shaohua | Institute of Geriatrics, Beijing Key Laboratory of Aging and Geriatrics, National Clinical Research Center for Geriatric Diseases, Second Medical Center, Chinese People's Liberation Army General Hospital, Beijing 100853, China | | | Li Xuehang | Institute of Geriatrics, Beijing Key Laboratory of Aging and Geriatrics, National Clinical Research Center for Geriatric Diseases, Second Medical Center, Chinese People's Liberation Army General Hospital, Beijing 100853, China
Chinese People's Liberation Army Medical School, Beijing 100853, China | | | Li Zhiqiang | Institute of Geriatrics, Beijing Key Laboratory of Aging and Geriatrics, National Clinical Research Center for Geriatric Diseases, Second Medical Center, Chinese People's Liberation Army General Hospital, Beijing 100853, China | | | Li Haowei | Institute of Geriatrics, Beijing Key Laboratory of Aging and Geriatrics, National Clinical Research Center for Geriatric Diseases, Second Medical Center, Chinese People's Liberation Army General Hospital, Beijing 100853, China | | | Li Rongrong | Institute of Geriatrics, Beijing Key Laboratory of Aging and Geriatrics, National Clinical Research Center for Geriatric Diseases, Second Medical Center, Chinese People's Liberation Army General Hospital, Beijing 100853, China
Chinese People's Liberation Army Medical School, Beijing 100853, China | | | Wang Jianhua | Institute of Geriatrics, Beijing Key Laboratory of Aging and Geriatrics, National Clinical Research Center for Geriatric Diseases, Second Medical Center, Chinese People's Liberation Army General Hospital, Beijing 100853, China | | | Yang Shanshan | Department of Disease Prevention and Control, First Medical Center, Chinese People's Liberation Army General Hospital, Beijing 100853, China | | | Zhao Yali | Central Laboratory, Hainan Hospital, Chinese People's Liberation Army General Hospital, Sanya 572013, China | | | Li Jing | Health Service Department, Fifth Medical Center, Chinese People's Liberation Army General Hospital, Beijing 100853, China | | | Zhu Qiao | Central Laboratory, Hainan Hospital, Chinese People's Liberation Army General Hospital, Sanya 572013, China | | | Ning Chaoxue | Central Laboratory, Hainan Hospital, Chinese People's Liberation Army General Hospital, Sanya 572013, China | | | Liu Miao | Department of Statistics and Epidemiology, Graduate School, Chinese People's Liberation Army General Hospital, Beijing 100853, China | liumiaolmbxb@163.com | | He Yao | Institute of Geriatrics, Beijing Key Laboratory of Aging and Geriatrics, National Clinical Research Center for Geriatric Diseases, Second Medical Center, Chinese People's Liberation Army General Hospital, Beijing 100853, China
State Key Laboratory of Kidney Diseases, Beijing 100853, China | yhe301@sina.com |
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| Abstract: |
| 目的 分析海南百岁老人抑郁症状与全因死亡风险间的关联。方法 基于中国海南百岁老人队列研究，对纳入基线且资料完整的1 002人随访其生存与死亡结局。抑郁症状根据简易老年抑郁量表（GDS-15）调查获得评分，并划分成正常（≤5分）、轻度抑郁（6~9分）和重度抑郁（≥10分）。采用Cox比例风险回归模型分析抑郁症状与全因死亡风险间的关联强度。结果 截至2021年5月31日，随访时间M（Q1，Q3）为4.16（1.31，5.04）年，死亡人数为522人，死亡密度为152.39/1 000人年。多因素Cox比例风险回归分析结果显示，在控制人口社会学特征、生活方式等协变量后，GDS-15评分每增加1分，全因死亡风险增加3.1%（HR=1.031，95%CI：1.002~1.061）；与正常百岁老人相比，重度抑郁者死亡风险增高35.9%（HR=1.359，95%CI：1.023~1.806），重度抑郁者平均减寿1.94年。在女性百岁老人中，相比于正常组，轻度抑郁和重度抑郁组死亡风险分别增加29.3%（HR=1.293，95%CI：1.053~1.590）和42.3%（HR=1.423，95%CI：1.047~1.935），重度抑郁者平均减寿1.71年。结论 海南百岁老人中抑郁症状与全因死亡风险增高及减寿相关。 |
| English Abstract: |
| Objective To examine the association between depression and all-cause death in centenarians in Hainan Province. Methods Based on China Hainan Centenarian Cohort Study, 1 002 centenarians with integral data were included in the baseline survey, follow up was conducted to collect the information about their survival status and death outcome. Depression was evaluated by the 15-item Geriatric Depression Scale (GDS-15) and based on the evaluation scores, the mental status of the centenarians was classified as: severe depressive disorder (MDD; score ≥10), minor depressive disorder (MnDD; score 6-9), and normal status (score ≤5). Multivariable-adjusted Cox proportional hazards regression models was used to estimate the hazard ratios (HRs) and 95%CIs. Results As of May 31st, 2021, a total of 522 deaths had been reported, with a mortality density of 152.39/1 000 person-years and a median follow up time M(Q1, Q3) of 4.16 (1.31, 5.04) years, in the centenarians. After adjusting the factors of socio-demographic characteristics and lifestyle, multivariate Cox regression analysis showed that the risk of all-cause mortality increased by 3.1% for every 1-point increase in GDS-15 score (HR=1.031, 95%CI: 1.002-1.061). Compared with centenarians with normal status, the risk of mortality in the centenarians with MDD increased by 35.9% (HR=1.359, 95%CI: 1.023-1.806), the centenarians with MDD had an average 1.94 years of life lost. Among the female centenarians, the risk of mortality in MnDD group and MDD group increased by 29.3% (HR=1.293, 95%CI: 1.053-1.590) and 42.3% (HR=1.423, 95%CI: 1.047-1.935) compared with normal group, those with MDD had an average 1.71 years of life lost. Conclusions Depression was related to the increased risk of all-cause death and life lost in the centenarians in Hainan. |
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