| 李雪航,李靖,王盛书,宋扬,刘少华,陈仕敏,李志强,李蓉蓉,李皓炜,杨姗姗,王建华,赵亚力,朱乔,甯超学,刘淼,何耀.海南百岁老人血压水平及相关因素与全因死亡关联的前瞻性队列研究[J].Chinese journal of Epidemiology,2023,44(1):115-121 |
| 海南百岁老人血压水平及相关因素与全因死亡关联的前瞻性队列研究 |
| Association of various levels of blood pressure and related factors with all-cause death in Hainan centenarians: a prospective cohort study |
| Received:April 14, 2022 |
| DOI：10.3760/cma.j.cn112338-20220414-00294 |
| KeyWord: 百岁老人 血压 全因死亡 体质指数 |
| English Key Word: Centenarian Blood pressure All-cause death Body mass index |
| FundProject:国家自然科学基金（82173589，82173590，81941021）；首都卫生发展科研专项（2022-2G-5031）；国家重点研发计划（2018YFC2000400） |
| Author Name | Affiliation | E-mail | | Li Xuehang | Institute of Geriatrics, Beijing Key Laboratory of Aging and Geriatrics, National Clinical Research Center for Geriatric Diseases, Second Medical Center, Chinese People's Liberation Army General Hospital, Beijing 100853, China
Chinese People's Liberation Army Medical School, Beijing 100853, China | | | Li Jing | Health Service Department, Fifth Medical Center, Chinese People's Liberation Army General Hospital, Beijing, 100853, China | | | Wang Shengshu | Institute of Geriatrics, Beijing Key Laboratory of Aging and Geriatrics, National Clinical Research Center for Geriatric Diseases, Second Medical Center, Chinese People's Liberation Army General Hospital, Beijing 100853, China
Department of Healthcare, Agency for Offices Administration, Central Military Commission, People's Republic of China, Beijing 100082, China | | | Song Yang | Institute of Geriatrics, Beijing Key Laboratory of Aging and Geriatrics, National Clinical Research Center for Geriatric Diseases, Second Medical Center, Chinese People's Liberation Army General Hospital, Beijing 100853, China
Health Corps, Special Combat Detachment of Xinjiang Armed Police Crops, Aksu 843000, China | | | Liu Shaohua | Institute of Geriatrics, Beijing Key Laboratory of Aging and Geriatrics, National Clinical Research Center for Geriatric Diseases, Second Medical Center, Chinese People's Liberation Army General Hospital, Beijing 100853, China | | | Chen Shimin | Institute of Geriatrics, Beijing Key Laboratory of Aging and Geriatrics, National Clinical Research Center for Geriatric Diseases, Second Medical Center, Chinese People's Liberation Army General Hospital, Beijing 100853, China | | | Li Zhiqiang | Institute of Geriatrics, Beijing Key Laboratory of Aging and Geriatrics, National Clinical Research Center for Geriatric Diseases, Second Medical Center, Chinese People's Liberation Army General Hospital, Beijing 100853, China | | | Li Rongrong | Institute of Geriatrics, Beijing Key Laboratory of Aging and Geriatrics, National Clinical Research Center for Geriatric Diseases, Second Medical Center, Chinese People's Liberation Army General Hospital, Beijing 100853, China
Chinese People's Liberation Army Medical School, Beijing 100853, China | | | Li Haowei | Institute of Geriatrics, Beijing Key Laboratory of Aging and Geriatrics, National Clinical Research Center for Geriatric Diseases, Second Medical Center, Chinese People's Liberation Army General Hospital, Beijing 100853, China | | | Yang Shanshan | Department of Disease Prevention and Control, First Medical Center, Chinese People's Liberation Army General Hospital, Beijing 100853, China | | | Wang Jianhua | Institute of Geriatrics, Beijing Key Laboratory of Aging and Geriatrics, National Clinical Research Center for Geriatric Diseases, Second Medical Center, Chinese People's Liberation Army General Hospital, Beijing 100853, China | | | Zhao Yali | Central Laboratory, Hainan Hospital, Chinese People's Liberation Army General Hospital, Sanya 572013, China | | | Zhu Qiao | Central Laboratory, Hainan Hospital, Chinese People's Liberation Army General Hospital, Sanya 572013, China | | | Ning Chaoxue | Central Laboratory, Hainan Hospital, Chinese People's Liberation Army General Hospital, Sanya 572013, China | | | Liu Miao | Department of Statistics and Epidemiology, Graduate School, Chinese People's Liberation Army General Hospital, Beijing 100853, China | liumiaolmbxb@163.com | | He Yao | Institute of Geriatrics, Beijing Key Laboratory of Aging and Geriatrics, National Clinical Research Center for Geriatric Diseases, Second Medical Center, Chinese People's Liberation Army General Hospital, Beijing 100853, China
State Key Laboratory of Kidney Diseases, Beijing 100853, China | yhe301@sina.com |
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| Abstract: |
| 目的 探讨我国海南百岁老人SBP及DBP水平及相关因素与全因死亡之间的关联。方法 数据来自中国海南百岁老人队列研究，采用前瞻性队列研究方法，纳入1 002名百岁老人。采用Cox比例风险回归模型，分析SBP和DBP水平及相关影响因素对全因死亡的影响。结果 截至2021年5月31日，中位随访时间为4.16年，死亡密度为15.24/100人年。人群按照SBP、DBP四等分后，SBP的Q1组和DBP的Q2组死亡密度最低（分别为12.73/100人年和14.10/100人年）。在总人群中，SBP水平与Q1组相比，Q2、Q3、Q4组与全因死亡均呈正相关。在女性中，SBP以Q1组为参考值，Q2、Q3和Q4组与死亡关联的HR值分别为1.343、1.355和1.420；DBP以Q2组作为参考值，Q1、Q3、Q4组与死亡关联的HR值分别为1.468、1.800和1.504，大致呈“U”形相关。交互作用分析发现，SBP与BMI之间存在相乘交互作用。结论 海南百岁老人的SBP和DBP水平与全因死亡存在关联；百岁老人的DBP可能存在死亡风险较低的适宜水平及范围；不同BMI状态可能影响血压水平与死亡结局的关联。 |
| English Abstract: |
| Objective To understand the associations of various levels of systolic and diastolic blood pressure levels and related factors with all-cause death in the centenarians in Hainan Province. Methods The data were obtained from China Hainan Centenarian Cohort Study, a prospective cohort study which included 1 002 centenarians. Cox proportional risk regression models were used to analyze the associations of blood pressure and related factors with all-cause death in the centenarians. Results As of May 31, 2021, with the median of the follow-up time of 4.16 years, and the mortality density had reach 15.24 per 100 person-years. After grouping by SBP and DBP quartiles, the Q1 of SBP and Q2 of DBP caused the lowest mortality density (12.73 per 100 person-years and 14.10 per 100 person-years relatively). In all the centenarians, compared with the Q1 of SBP (≤137 mmHg, 1 mmHg=0.133 kPa), Q2, Q3 and Q4 were all positively associated with all-cause death. In the female population, the HRs of SBP's Q2, Q3 and Q4 were 1.343, 1.355 and 1.420 respectively (Q1 as reference), and the HRs of DBP's Q1, Q3 and Q4 were 1.468, 1.800 and 1.504 respectively (Q2 as reference), showing a roughly U-shaped association. Interactive analysis showed multiplicative interaction between SBP and BMI. Conclusions In the centenarians in Hainan, different levels of systolic and diastolic blood pressure were associated with all-cause death. In the centenarians, DBP might have a suitable level or range in which the risk of death is relatively low. Different BMI status might affect the associations of blood pressure levels with death outcomes. |
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