宁波市鄞州区2016-2021年系统性红斑狼疮发病的流行病学研究

赖雪峰; 刘志科; 沈鹏; 孙烨祥; 陆怀初; 詹思延; 林鸿波

Abstract

赖雪峰,刘志科,沈鹏,孙烨祥,陆怀初,詹思延,林鸿波.宁波市鄞州区2016-2021年系统性红斑狼疮发病的流行病学研究[J].Chinese journal of Epidemiology,2023,44(7):1080-1085

宁波市鄞州区2016-2021年系统性红斑狼疮发病的流行病学研究

Epidemiological study of incidence of systematic lupus erythematosus in Yinzhou, Ningbo, 2016-2021

Received:December 25, 2022

DOI：10.3760/cma.j.cn112338-20221225-01081

KeyWord: 系统性红斑狼疮发病密度流行病学特征

English Key Word: Systematic lupus erythematosus Incidence density Epidemiological characteristics

FundProject:比尔及梅琳达·盖茨基金会（INV-035024）；国家自然科学基金（81973146）

Author Name	Affiliation	E-mail
Lai Xuefeng	Key Laboratory of Epidemiology of Major Diseases, Ministry of Education/Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China
Liu Zhike	Key Laboratory of Epidemiology of Major Diseases, Ministry of Education/Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China
Shen Peng	Yinzhou District Center for Disease Control and Prevention of Ningbo, Ningbo 315199, China
Sun Yexiang	Yinzhou District Center for Disease Control and Prevention of Ningbo, Ningbo 315199, China
Lu Huaichu	Yinzhou District Center for Disease Control and Prevention of Ningbo, Ningbo 315199, China
Zhan Siyan	Key Laboratory of Epidemiology of Major Diseases, Ministry of Education/Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China	siyan-zhan@bjmu.edu.cn
Lin Hongbo	Yinzhou District Center for Disease Control and Prevention of Ningbo, Ningbo 315199, China	lin73160@163.com

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Abstract:

目的描述2016-2021年宁波市鄞州区系统性红斑狼疮（SLE）发病密度及其在不同年龄、性别的分布情况。方法基于鄞州区域健康信息平台2015-2021年的数据开展回顾性队列研究，纳入鄞州区常住居民，利用《国际疾病分类》第十版编码“M32”或中文文本“狼疮”模糊匹配的方式识别出SLE疑似病例。提取疑似病例的门/急诊和住院记录信息后，采用2012年系统性红斑狼疮国际协作组和2019年欧洲抗风湿病联盟联合美国风湿病学会分类标准进行病例验证，依据验证结果确定识别SLE病例的算法，并以1年为洗脱期识别新发病例。采用泊松分布估算SLE发病密度及其95%CI。结果 2016-2021年鄞州区累计登记的常住人口共1 551 921人，其中女性占51.52%，入组年龄的M（Q₁，Q₃）为40.38（27.54，53.54）岁，随访时间M（Q₁，Q₃）为3.83（0.41，5.83）年。SLE新发病例451例，其中女性352例（78.05%）。总人群6年发病密度为8.14/10万人年（95%CI：7.41/10万人年~8.93/10万人年），男性发病密度为3.68/10万人年（95%CI：2.99/10万人年~4.48/10万人年），女性发病密度为12.37/10万人年（95%CI：11.11/10万人年~13.73/10万人年）。男性的发病密度在20~29岁出现小高峰，从40岁开始随着年龄的增长不断升高。女性发病密度在20~29岁最高（16.57/10万人年），30~79岁均维持在较高水平。2016-2021年鄞州区的SLE发病密度无随时间变化的趋势（男性：P=0.848；女性：P=1.000）。结论 2016-2021年鄞州区SLE发病密度与我国其他地区相当。SLE在女性中高发，尤其对中老年人及年轻女性影响较大。

English Abstract:

Objective To characterize the incidence density of systematic lupus erythematosus (SLE) in Yinzhou District of Ningbo from 2016 to 2021, and compare the age and gender specific differences. Methods A retrospective cohort study was conducted based on the related data from 2015 to 2021 collected from the Health Information Platform of Yinzhou. Suspected SLE cases in local residents were identified by fuzzy matching of International Classification of Diseases 10^th edition code "M32" or Chinese text "lupus". The classification criteria from Systemic Lupus International Collaboration Clinics-2012 and The European League Against Rheumatism/American College of Rheumatology-2019 were used for case verification. SLE cases were identified with specific algorithm based on verification results, and new cases were identified with 1 year as the washout period. The incidence density and 95%CI were estimated by Poisson distribution. Results From 2016 to 2021, a total of 1 551 921 permanent residents were registered in Yinzhou, in whom 51.52% were women. The M(Q₁,Q₃) age at enrollment was 40.38 (27.54, 53.54) years. The M(Q₁,Q₃) of follow-up person-years was 3.83 (0.41, 5.83) years. There were 451 new SLE cases, in which 352 were women (78.05%). The 6-year incidence density was 8.14/100 000 person-years (95%CI:7.41/100 000 person-years-8.93/100 000 person-years) for the total population, 3.68/100 000 person-years (95%CI:2.99/100 000 person-years-4.48/100 000 person-years) for men and 12.37/100 000 person-years (95%CI:11.11/100 000 person-years- 13.73/100 000 person-years) for women. The incidence density in men appeared a small peak at 20-29 years old, and began to increase with age from 40 years old. The incidence density in women was highest in age group 20-29 years (16.57/100 000 person-years) and remained to be high until 30-79 years old. The incidence density of SLE in Yinzhou show no significant temporal trend from 2016 to 2021 (men:P=0.848; women:P=1.000). Conclusions The incidence density of SLE in Yinzhou from 2016 to 2021 was similar to those of other areas in China. SLE has a high incidence in women, especially in the young and elderly, suggesting that more attention should be paid to the diagnosis and treatment of SLE in women.

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