文章摘要
洪德庆,李建树,王和玉,周详,戴汉民.106例HBsAg携带者第7~12年追踪观察及影响转归因素的探讨[J].中华流行病学杂志,1985,6(4):223-226
106例HBsAg携带者第7~12年追踪观察及影响转归因素的探讨
A Follow-up Study on 106 HBsAg Carriers between 7-12 years and on Factors Influencing its outcome
收稿日期:  出版日期:2021-05-22
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作者单位
洪德庆 南京医学院 
李建树 南京医学院 
王和玉 南京医学院 
周详 南京医学院 
戴汉民 南京医学院 
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中文摘要:
      对106例HBsAg携带者进行了7~12年(平均9.5年)的随访。其转归:康复9例、急性肝炎3例,慢迁肝6例、慢活肝13例、肝硬变1例。死亡3例(原发性肝癌。慢性重症肝炎,食道癌各1例)、轻微肝功能损害12例。病后携带23例。无症状携带者36例,在观察期间,无肝炎史的93例携带者有40例发生急性肝炎,占43.0%。HBsAg阴转13例,阴转率为12.6%,阴转时间平均5.4年。高滴度HBsAs携带者和HBeAg阳性者,其HBsAg阴转率极显著低于低滴度携带者和HBeAg阴性者;而肝炎发病率、各种肝病发生率和肝功能异常率又显著高于后者。作者认为,HBsAg滴度高和伴有HBeAg是影响HBsAs携带者转归的重要因素。
英文摘要:
      A follow-up observation was carried out of 106 HBsAg carriers over seven to twelve years (nine and half years in average). The results:nine persons recovered, three suffered from acute hepatitis, six chronic persistent hepatitis, thirteen chronic active hepatitis, one hepatocirrhosis, three died of primary hepatic carcinoma, chronic gravis hepatitis or esophagcal carcinoma, twelve subjected to slight liver function damage, twenty-three carried HBsAg after hepatitis, thirty-six being asymptomatic carriers. During observation period, forty out of ninty-three who had been HBsAg positive with no hepatitis history suffered from acute hepatitis,amounted to 43.0%. Thirteen HBsAg carriers negative converted, the conversion rate being 12.6% and the average conversion time being 5.4 years. The negative-conversion rate of HBsAg carriers with high titre or HBeAg positive was significantly lower than those with low titre or HBeAg negative; vice versa, the incidences of hepatitis and other kinds of liver diseases & live r function damage of the former were significantly higher than that of the latter. The auther considered that high titre HBsAg and HBeAg positive are imporstant factors influencing the prognosis of HBsAg carriers.
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