文章摘要
黄芬,董亚珞,王占英,赵桂珍,李颖,苏德元.沈阳地区不同人群HCV感染及HCV基因型分布研究[J].中华流行病学杂志,1998,(3):134-137
沈阳地区不同人群HCV感染及HCV基因型分布研究
Study on HCV Infection and the Distribution of HCV Genotypes in Different Populations in Shenyang Area
收稿日期:1997-10-31  出版日期:2014-09-16
DOI:
中文关键词: HCV感染;HCV基因型
英文关键词: HCV infection;HCV genotypes
基金项目:
作者单位
黄芬 中国医科大学附属第二临床医院传染科, 沈阳 110003 
董亚珞 中国医科大学附属第一临床医院 
王占英 中国医科大学附属第二临床医院传染科, 沈阳 110003 
赵桂珍 中国医科大学附属第二临床医院传染科, 沈阳 110003 
李颖 中国医科大学附属第二临床医院传染科, 沈阳 110003 
苏德元 中国医科大学附属第二临床医院传染科, 沈阳 110003 
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中文摘要:
      应用酶联免疫检测技术,检测沈阳地区3 902例不同人群血清的抗-HCV,并应用引物特异PCR法对其中100例血清标本进行HCV基因分型。结果:正常人群抗-HCV阳性率为0.42%~1.66%;输血后及散发性肝炎(除外HAV、HBV、EBV、CMV感染)、乙型肝炎、肝炎后肝硬化(除外HBV感染)、原发性肝癌等组抗-HCV阳性率显著高于无输血史的非肝病病人组(P<0.01);100例血清标本中HCV-Ⅱ型感染占58%、HCV-Ⅲ型27%、Ⅱ/Ⅲ混合型14%、未分型1%,正常人群HCV感染者中HCV基因型以Ⅲ型为主(80%),丙型肝炎后肝硬化病人HCV基因型以Ⅱ型为主(91.7%)。提示:各类肝病病人是HCV感染的高危人群;沈阳地区HCV感染以Ⅱ型为主,其次为Ⅲ型及Ⅱ/Ⅲ混合型,HCV基因型可能与丙型肝炎病情轻重有关。
英文摘要:
      3902 serum samples in different populations were tested for anti-HCV by ELISA.Among 100 samples of them,genotypes of HCV were detected by PCR with type-specific primers.The results showed:a)anti-HCV positive rates in general populations were 0.42%-1.66%;b)anti-HCV positive rates in the group of post-transfusion hepatitis and sporadic hepatitis (excluding HAV,HBV,EBV,CMV infection),hepatitis B post hepatitis cirrhosis (excluding HBV infection) and primary hepatocarcinoma were significantly higher than the group of patients without liver diseases or the group of patients without transfusion (P<0.01); c) in HCV genotyping,HCV-Ⅱ,HCV-Ⅲ,Ⅱ/Ⅲ mixed type were 58%,27%,14% respectively.The rate of infection with HCV-Ⅲ was 80% in normal population but 91.7% with type Ⅱ HCV in the group of patients with cirrhosis.These results suggested:(1)patients with different liver diseases were under high risk of HCV infection;(2)type HCV-Ⅱ was predominant followed by HCV-Ⅲ as well as Ⅱ/Ⅲ mixed in HCV genotype distribution of Shenyang area.Different genotypes of HCV might be related to the severity of hepatitis C.
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