| 王冬萌,高文静,吕筠,余灿清,王胜锋,逄增昌,俞敏,汪华,吴先萍,董忠,吴凡,江国虹,王晓节,刘彧,邓健,陆林,曹卫华,李立明.中国成年双生子人群的冠心病遗传度估计[J].中华流行病学杂志,2020,41(5):700-704 |
| 中国成年双生子人群的冠心病遗传度估计 |
| Heritability of coronary heart disease, based on the data from the Chinese adult twins |
| 收稿日期:2019-08-21 出版日期:2020-05-12 |
| DOI：10.3760/cma.j.cn112338-20190821-00612 |
| 中文关键词: 冠心病 双生子研究 遗传度 |
| 英文关键词: Coronary heart disease Twin study Heritability |
| 基金项目:公益性行业科研专项（201502006，201002007）；国家自然科学基金（81711530051） |
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| 中文摘要: |
| 目的 分析中国成年双生子人群的冠心病遗传度。方法 利用中国双生子登记系统在11省、市募集的20 477对≥ 25岁同性别双生子，构建结构方程模型计算遗传度。结果 调整年龄、性别后，冠心病的遗传度为0.75（0.68~0.81）。亚组分析显示≥ 40岁组和女性人群中，冠心病患病主要受遗传因素的影响；而25~39岁组和男性的患病主要受环境因素的影响。结论 冠心病患病受遗传和环境因素的影响，且遗传度较高。 |
| 英文摘要: |
| Objective To analyze the heritability of coronary heart disease (CHD) among the Chinese twin adults. Methods A total of 20 477 same-sex twin pairs aged 25 years and older from the Chinese National Twin Registry were interviewed. Structure equation model was used to estimate the heritability of CHD. Results After adjusting for age and gender, the overall heritability of CHD was 0.75(0.68-0.81). Stratified analyses showed that genetic factors play a more important role in CHD incidence in ≥ 40 years or female twins. While the development of CHD was mainly influenced by environmental factors in 25-39 years or male twins. Conclusion CHD is influenced by both genetic and environmental factors and the heritability is high. |
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