文章摘要
乔世杰,周素娟,徐璐璐,陈潇潇,许圆圆,沈伟伟,刘星,林海江,何纳.台州市2017-2018年新报告HIV/AIDS巨细胞病毒血症现患率及影响因素研究[J].中华流行病学杂志,2021,42(2):316-320
台州市2017-2018年新报告HIV/AIDS巨细胞病毒血症现患率及影响因素研究
Prevalence and correlates of plasma cytomegalovirus viremia among newly reported HIV/AIDS patients in Taizhou city, 2017-2018
收稿日期:2020-04-20  出版日期:2021-02-24
DOI:10.3760/cma.j.cn112338-20200420-00601
中文关键词: 艾滋病病毒/艾滋病;巨细胞病毒;病毒血症;现患率;影响因素
英文关键词: HIV/AIDS;Cytomegalovirus;Viremia;Prevalence;Related factors
基金项目:国家科技重大专项(2018ZX10721102-004)
作者单位E-mail
乔世杰 复旦大学公共卫生学院流行病学教研室, 公共卫生安全教育部重点实验室, 上海 200032  
周素娟 复旦大学公共卫生学院流行病学教研室, 公共卫生安全教育部重点实验室, 上海 200032  
徐璐璐 复旦大学公共卫生学院流行病学教研室, 公共卫生安全教育部重点实验室, 上海 200032  
陈潇潇 台州市疾病预防控制中心 318000  
许圆圆 台州市疾病预防控制中心 318000  
沈伟伟 台州市疾病预防控制中心 318000  
刘星 复旦大学公共卫生学院流行病学教研室, 公共卫生安全教育部重点实验室, 上海 200032  
林海江 台州市疾病预防控制中心 318000 84800166@qq.com 
何纳 复旦大学公共卫生学院流行病学教研室, 公共卫生安全教育部重点实验室, 上海 200032 nhe@fudan.edu.cn 
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中文摘要:
      目的 了解2017-2018年台州市新报告且未接受抗病毒治疗(ART)的HIV/AIDS血浆巨细胞病毒血症现患率及其影响因素。方法 收集台州市新报告且未接受ART的成年HIV/AIDS血浆样本,提取核酸后采用荧光定量PCR检测巨细胞病毒DNA水平,采用单因素与多因素logistic回归分析其影响因素。结果 研究对象612例HIV/AIDS中,男性480例(78.4%),年龄>60岁125例(20.4%),同性性传播者177例(28.9%),异性性传播者430例(70.3%)。巨细胞病毒血症现患率为13.4%(82/612)。多因素logistic回归分析结果显示,CD4+T淋巴细胞计数(CD4)≤ 200个/μl者现患巨细胞病毒血症的风险显著高于CD4>500个/μl者(OR=5.10,95%CI:1.74~14.96,P=0.003);82例现患巨细胞病毒血症者的血浆巨细胞病毒DNA载量(log10)中位数为1.57(P25P75:1.04,2.13),CD4 ≤ 200个/μl者的巨细胞病毒载量最高(P<0.01)。结论 2017-2018年台州市新报告未接受ART的HIV/AIDS中,巨细胞病毒血症现患率与免疫缺陷状态显著关联,巨细胞病毒血症对HIV/AIDS病程的影响有待进一步研究。
英文摘要:
      Objective To study the prevalence and correlates of plasma cytomegalovirus (CMV) viremia among newly reported antiretroviral therapy (ART)-naive HIV/AIDS patients in Taizhou during 2017-2018.Methods CMV DNA was measured in plasma specimens of newly reported ART-naive HIV/AIDS patients by quantitative PCR. Both univariable and multivariable logistic regression analyses were carried out to evaluate CMV viremia correlations among the individuals.Results Of 612 HIV/AIDS patients, 480 (78.4%) were male, 125 (20.4%) were over 60 years old, 177 (28.9%) were infected via homosexual transmission, and 430 (70.3%) via heterosexual transmission. The prevalence of CMV viremia among HIV/AIDS patients was 13.4% (82/612). Multivariable logistic regression analysis showed that the risk of CMV viremia in CD4+ lymphocyte cells counts (CD4+) ≤ 200 cells/μl group was higher than CD4 counts >500 cells/μl (OR=5.10, 95%CI:1.74-14.96, P=0.003); The median CMV DNA level (log10) of 82 viremic patients was 1.57 (P25,P75:1.04,2.13); Viremic patients with CD4 counts ≤ 200 cells/μl had the highest CMV viral load (P<0.01).Conclusions Among ART-naive HIV/AIDS patients, the prevalence of CMV viremia was significantly associated with immunodeficiency status. Further research is needed to evaluate the association between CMV viremia and the course of HIV infection.
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