| 闫慧,赵静,刘德军,陈光辉.河南省2 110例宫颈癌患者人乳头瘤病毒感染状况分析[J].中华流行病学杂志,2021,42(5):914-917 |
| 河南省2 110例宫颈癌患者人乳头瘤病毒感染状况分析 |
| Analysis on human papillomavirus infection in 2 110 patients with cervical cancer in Henan province |
| 收稿日期:2020-07-29 出版日期:2021-05-27 |
| DOI：10.3760/cma.j.cn112338-20200729-00992 |
| 中文关键词: 宫颈癌 人乳头瘤病毒 亚型 |
| 英文关键词: Cervical cancer Human papillomavirus Subtype |
| 基金项目: |
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| 中文摘要: |
| 目的 调查来自河南省的2 110例宫颈癌患者人乳头瘤病毒（HPV）感染状况，分析其主要感染亚型。方法 采用PCR和导流杂交技术，对来自河南省的2 110例宫颈癌患者进行HPV分型检测，并对检测结果进行分析。结果 2 110例宫颈癌患者中，检出HPV感染者1 856例，感染率为87.96%（95%CI：86.57%~89.35%），感染率最高的6个亚型依次为HPV16、58、18、52、35、33。HPV阳性宫颈癌患者以单一感染为主（77.48%），二重感染次之（16.76%）。HPV16亚型感染率为60.19%，在单一和多重感染中均占有主导地位。HPV阳性的宫颈癌患者中，高危亚型检出且被九价HPV疫苗覆盖1 599例，覆盖率为86.15%（1 599/1 856）。宫颈癌患者主要分布于40~岁年龄段。不同年龄段宫颈癌患者的HPV优势亚型有所不同，但HPV16亚型均处于主导地位。结论 本研究中宫颈癌患者HPV主要感染亚型依次为HPV16、58、18、52、35、33，感染类型以单一感染为主，40~岁年龄段患者较多。 |
| 英文摘要: |
| Objective To explore human papillomavirus (HPV) infection status in 2 110 patients with cervical cancer in Henan province and analyze the main infection subtypes. Methods A total of 2 110 patients with cervical cancer were detected for HPV subtypes by flow-through hybridization after PCR. The results were analyzed. Results Among 2 110 patients with cervical cancer, 1 856 were detected to be HPV positive and the infection rate was 87.96%(95%CI:86.57%-89.35%). The top six genotypes were HPV16, 58, 18, 52, 35 and 33. Single infection was the main type of infection in HPV positive cervical cancer patients (77.48%), and double infection was the second type infection(16.76%). The infection rate of HPV16 was 60.19%, occupying a predominant position in single or multiple infections. Among HPV positive cervical cancer patients, 1 599 cases were detected to be infected with high-risk subtypes and covered by nine-valence HPV vaccine, and the coverage rate reached 86.15% (1 599/1 856). Cervical cancer patients were mainly distributed in age group 40- years. The main HPV subtypes of cervical cancer patients were different among different age groups, but HPV16 subtype was in a predominant position in any age group.Conclusions The main subtypes of HPV infection were HPV16, 58, 18, 52, 35 and 33 in cervical cancer patients in this study. The main infection type was single infection. There were more cervical cancer patients in age group 40- years. |
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