| 蔡欢乐,杜志成,王莹,朱淑明,李菁华,张王剑,顾菁,郝元涛.HBV感染人群中运动与非酒精性脂肪性肝病的关联性分析[J].中华流行病学杂志,2023,44(3):445-451 |
| HBV感染人群中运动与非酒精性脂肪性肝病的关联性分析 |
| Association between physical exercise and non-alcoholic fatty liver disease in people infected with hepatitis B virus |
| 收稿日期:2022-09-07 出版日期:2023-03-14 |
| DOI：10.3760/cma.j.cn112338-20220907-00769 |
| 中文关键词: 非酒精性脂肪性肝病 运动 乙型肝炎病毒 |
| 英文关键词: Non-alcoholic fatty liver disease Exercise Hepatitis B virus |
| 基金项目:国家科技重大专项（2018ZX10715004） |
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| 中文摘要: |
| 目的 分析HBV感染人群中运动与非酒精性脂肪性肝病（NAFLD）患病的关联。方法 基于2016-2020年国家科技重大专项课题招募的3 813例HBV感染者，收集研究对象的患病情况、运动情况及其他协变量信息。采用logistic回归探讨运动与该人群NAFLD患病的关联，并进行亚组分析探讨效应修饰因子。结果 共2 259例HBV感染者，患有NAFLD者454例（20.10%）。校正协变量后，发现中强度运动为NAFLD的保护因素（OR=0.66，95%CI：0.46~0.94）。亚组分析结果显示，可能在女性（OR=0.61，95%CI：0.36~1.01）、年龄<45岁（OR=0.24，95%CI：0.06~0.80）、小学及以下文化程度（OR=0.16，95%CI：0.04~0.49）、家庭年收入<3万元（OR=0.39，95%CI：0.16~0.89）、3万~8万元（OR=0.64，95%CI：0.40~1.00）、有高血压病史（OR=0.45，95%CI：0.21~0.88）、BMI≥24.0 kg/m2（OR=0.66，95%CI：0.43~1.01）、每日蔬果摄入量较多（OR=0.61，95%CI：0.38~0.97）、每日肉类摄入量较多（OR=0.49，95%CI：0.23~0.97）、不吸烟（OR=0.66，95%CI：0.45~0.95）和无二手烟暴露史（OR=0.61，95%CI：0.37~0.97）的人群中，中强度运动对NAFLD的保护效应更强。结论 中强度运动在HBV感染者中与NAFLD存在关联，具有保护效应。女性、低龄、较低文化程度、较低家庭年收入、有高血压病史、BMI偏高、每日蔬果与肉类摄入量较多、不吸烟和无二手烟暴露史的人群可能对该保护效应更敏感。 |
| 英文摘要: |
| Objective To investigate the association between physical exercise and non-alcoholic fatty liver disease (NAFLD) in people infected with HBV. Methods The information about the 3 813 participants infected with HBV, including the prevalence of NAFLD, prevalence of physical exercise and other covariates, were collected from the National Science and Technology Major Project of China during 2016-2020. The logistic regression model was used to evaluate the association between physical exercise and NAFLD in HBV infected patients, and subgroup analysis was performed to identify the effect modifiers. Results A total of 2 259 HBV infected participants were included in the final analysis and 454 (20.10%) had NAFLD. After adjusting for covariates, we found that moderate physical exercise was a protective factor for NAFLD (OR=0.66, 95%CI:0.46-0.94). Subgroup analysis suggested that the protective effect of moderate physical exercise on NAFLD might be stronger in women (OR=0.61, 95%CI:0.36-1.01), those <45 years old (OR=0.24, 95%CI:0.06-0.80), those who had low education level (OR=0.16, 95%CI:0.04-0.49), those who had low annual income (OR=0.39, 95%CI:0.16-0.89 for <30 000 yuan RMB;OR=0.64, 95%CI:0.40-1.00 for 30 000-80 000 yuan RMB), those who had hypertension (OR=0.45, 95%CI:0.21-0.88), those with BMI ≥ 24.0 kg/m2 (OR=0.66, 95%CI:0.43-1.01), those who had more daily fruit or vegetable intake (OR=0.61, 95%CI:0.38-0.97), those who had more daily meat intake (OR=0.49, 95%CI:0.23-0.97), and those who had no smoking history (OR=0.66, 95%CI:0.45-0.95) or passive smoking exposure (OR=0.61, 95%CI:0.37-0.97). Conclusions Among HBV infected patients, moderate physical exercise was negatively associated with the prevalence of NAFLD. Women, young people, those who had low education level, those who had low annual income, those with hypertension, those with high BMI, those who had more daily fruit or vegetable and meat intakes, and those who had no smoking history or passive smoking exposure might be more sensitive to the protective effect. |
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