| 徐福根,钟银德,程洪亮,黄志诚,傅强,闻洪根,姚怀芳.一次农村麻疹爆发流行的血清流行病学分析[J].Chinese journal of Epidemiology,1983,4(1):8-11 |
| 一次农村麻疹爆发流行的血清流行病学分析 |
| An Outbreak of Measles in a Rural District & its Sero-epidemiological Analysis |
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| Abstract: |
| 1980年浙北一个农村公社发生麻疹爆发,发病率为18.71‰,其中小学生发病率高达24.15%。119名无麻疹既往史小学生血凝抑制抗体测定结果,抗体阴性率31.09%,GMT7.86,提出儿童免疫水平低是此次麻疹爆发的主要原因,并对造成儿童免疫水平低的可能因素进行了讨论。此外,观察了麻疹爆发前后小学生的抗体动态变化以及发病情況,发现接触麻疹后低抗体者(滴度为2)可发病,滴度≤64者可发生隐性感染;无麻疹既往史小学生的感染率64.7%,显性与隐性感染之比为1.03:1,有麻疹既往史儿童也有24%隐性再感染。 |
| English Abstract: |
| An outbreak of measles in a people's commune in northern Zhejiang Province was investigated in 1980. The total rate of incidence was 18.71 per thousand, but that of school children amounted to 24.15%. Hemagglutination inhibition test was carried out in 119 pupils without history of measles. The antibody-negative rate was 31.09%, and geometric mean antibody titer was 7.86. The main cause of this outbreak was likely due to the relatively low level of immunity, and the probable factors relevant to it were discussed. Moreover, the dynamics of antibody level and the prevalence of the disease in pupils were observed before and after the outbreak. It was demonstrated that children with low specific antibody titer (1:2) were liable to measles when exposed to the infected individual, and that inapparent infection might occur in those with antibody level≤1:64. The rate of the infection among pupils without history of measles was as high as 64.7%. the ratio of apparent to subclinical infection was 1.03:1. Reinfection without symptoms in pupils with history of measles was revealed as high as 24%. |
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