| 顾彬昌,高汝聂,吴永健,王学励,王圣丽,沈胜德,张旦华,黄毓龙,屠基陶,高玉堂.原发性肝细胞癌相对高低发区乙肝病毒感染情况的比较[J].Chinese journal of Epidemiology,1983,4(1):37-42 |
| 原发性肝细胞癌相对高低发区乙肝病毒感染情况的比较 |
| Comparision of the Presence or Absence of Early Hepatitis B Viral (HBV) Infections Among Population in Foci of Primary Hepatoma With Relatively High and Low Incidence Rates |
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| Abstract: |
| 本文报告了在肝癌高发区上海市崇明县内的相对高,低发地区对自然人群抽样调查HBV感染情况的结果。肝癌相对高、低发区居民之间,HBsAg阳性率的差别不显著,但抗HBs的阳性率低发区显著高于高发区,女性显著高于男性,因而提示对HBV的免疫水平可能是宿主受到HBV感染后是否发展为肝癌的极重要因素。结合崇明县的肝癌流行病学特点和黄曲霉毒素的污染情況,提示在幼年感染HBV的基础上,黄曲霉毒素等因素对肝脏的进一步损害影响和加快了癌变速度,或者黄曲霉毒素等的侵害造成机体对HBV感染的免疫应答缺陷,加速了HBV基因整合和参入宿主肝细胞,可能是导致肝癌高发和发病年龄提前的原因。 |
| English Abstract: |
| This paper reported different degree of epidemic conditions of hepatitis B viral infections obtained by sampling natural populations in those foci with relatively high and low rates of incidence of primary hepatic cancer in Chongming County, Shanghai municipality, where the disease was found prevalent. The results indicated that the rates of positive reaction to HBsAg presented no significant difference between sera of inhabitants from high and low foci of liver malignancy. In cases where anti-HBs in sera were examined, however, the rate of positive reaction of sera obtained from the inhabitants in the low foci was significantly higher than those obtained from the inhabitants in relatively high foci. Results also indicated that female inhabitants had significantly higher rate than those of male inhabitants. It was suggested that the immune level against HBV infection might be one of the important factors determining whether hepatoma would eventually develop into malignant form after infection by HBV. In Chongming County, there were evidences suggesting contamination with aflatoxin together with early damages of liver as a result of an infection with HBV. in childhood, a condition which promoted an accelerated growth of hepatoma. The injury caused by aflatoxin might produce a deficient immune response of the body against HBV infections. Consequently, it might accelerate the integration of HBV genes into hepatic cells of the host, thus it might help explaining why there existed a high morbidity rate of liver cancer and an earlier incidence of hepatic carcinoma occured in Chongming County than elsewhere in the municipality. |
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