| 邢光辉,吴仲君,倪仲文,唐恩洁,熊建国,罗华堂,王文琦,罗费嘉,向毅.流行性出血热免疫功能动态变化及发病机理的探讨[J].Chinese journal of Epidemiology,1983,4(5):288-291 |
| 流行性出血热免疫功能动态变化及发病机理的探讨 |
| The Kinetic Changes of Immunization and Pathogenesis of EHF |
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| Abstract: |
| 本文对四川省南充地区61例流行性出血热患者的免疫功能状态进行了系统观察。结果表明所有患者表现为细胞免疫功能降低、血清补体含量下降,体液免疫异常。其改变的程度与病程演变、病情轻重有一定的相关关系。血清IgM、IgA、IgG的动态变化规律,似符合初次感染免疫反应的特点。 |
| English Abstract: |
| A sequential observation of E-rosette, plasma immunologlobins and activation of the first and third components of complement (Cl and C3) as well as reievant laboratory tests were carried out in 61 patients with epidemic hemorrhagic fever(EHF) who were admitted to Nanchong District Hospital, Sichuan Province in 1981. Data obtained showed that immunological functions of all the 61 patients were significantly changed in comparision with the normal persons, i.e. depression of cell-ularimmunity, increased extent of activation of Cl and C3 and abnormal humoral immunity.lt was found that the extent of supression of cellular immunity and the extent of Cl and C3 activation were closely correlated with the severity and course of the disease.The patterns of the kinetic changes of serum lgM, IgA and IgG were compatible with that of primary infection. |
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