| 王滨有,张继伟,袁有和,周崑,刘其梅,桑伊敏,杨逸梅,刘玉凤,张立珍.新生儿先天性畸形病因的配对调查[J].Chinese journal of Epidemiology,1984,5(2):81-84 |
| 新生儿先天性畸形病因的配对调查 |
| Etiological Survey on Malformation of Newborn |
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| Abstract: |
| 本次调查的新生儿先天性畸形的发生率为2.14%，畸形儿母亲分娩时的年龄多集中在25~34岁。且多数为一孕一产（76.67%）。通过配对的病例对照调查发现先天性畸形的发生有明显的家族聚集现象（χ2=54.06，P<0.005）.并发现新生儿先天性畸形的发生与其母亲在妊娠头三个月内发生感染（χ2=13.88 P<0.005，RR=6.71）、接触毒物（χ2=5.79，P<0.05，RR=5.0），生殖道出血（χ2=4.0，P<0.05，RR=5.67），严重精神刺激（χ2=14.06，P<0.005，RR=33.0），二种以上因素的协同作用（χ2=18.58，P<0.005，RR=8.14）及近亲婚配等有明显联系。未发现与用药（χ2=3.70 P>0.05）、慢性病（χ2=2.08，P>0.05）、接触X线、外伤等有明显联系。两组均无烟酒嗜好。 |
| English Abstract: |
| The total incidence of congenital malformation in newborn babies was 2.14% (91/4,255). Most of the mothers giving birth to malformed newborn babies were in the 25~34 age group (89.6%). 76.67% (46/60) of mothers of the case-group was primip-ara.By means of the case-control study, it was found that the congenital had an evident tendency of familial aggregation (P<0.005). The congenital malformation had a close relationship with the followingfactors occurring in the first trimester of the mothers pregnancy.They were:infection (χ2=13.88,P<0.005 RR=6.71), contact with poisonous substances (χ2=5.79, P<0.05 RR=5.0), bleeding from the reproductive tract (χ2=4.0 P<0.05. RR=5.67)) serious emotional upset (χ2=14.06 P<0.005 RR=33.0), combination effect of two or more factors (χ2=18.58, P<0.005. RR=8.14), and close relativemarriage.But no could be found among the use of drugs (χ2=3.70 P>0.05), chronic illness (χ2=2.08 P>0.05), contact with X-ray and the mothers' wound.Nobody in the two groups had the habit ofsmoking and drinking. |
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