| 粱瑞林,苏启棠.无症状乙型肝炎表面抗原携带状态母-婴传播的研究[J].Chinese journal of Epidemiology,1984,5(3):138-142 |
| 无症状乙型肝炎表面抗原携带状态母-婴传播的研究 |
| A Study on Mother-to-infant transmission of Asymptomatic HBsAg Carrier State |
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| Abstract: |
| 本文报告对24名无症状HBsAg携带者母亲及其婴儿定期随访一年，其中11名（46%）婴儿HBsAg阳性。乳汁、唾液和脐带血标本的HBsAg阳性率分别为15.8%、22%和3.6%。HBsAg滴度>1：128和分泌物（乳汁或唾液）中HBsAg阳性母亲的婴儿具有较高的感染危险性。婴儿的感染与父亲HBsAg阳性无密切关系，说明感染来自母亲。研究结果表明，无症状HBsAg阳性母亲是乙型肝炎重要的传染源之一。提示母-婴传播的主要方式可能是在产程中经粘膜及口传播和生后密切接触传播。 |
| English Abstract: |
| A periodic follow-up study of 24 asymptomatic HBsAg carrier mothers and their infants aged up to 12 months was carried out for one year.HBsAg positive results were found in 11 (46%) infants.Using-RPHA, HBsAg was detected in 15.8% of the reast milk samples, terted 22.0% of saliva samples from mothers and 3.6% of cord blood samples from newborns.Babies whose mothers showed HBsAg-positive in their secretions (breast milk or saliva) with a titer of>1:128 in the blood had higher of being infected.No close relationship was found between infants' infection and their fathers' HBsAg-positivity. It suggested that the infants were infected by their mothers. The result showed that mothers who were asymptomatic HBsAg carriers were prone to be important sources of infection of hepatitis B. It implied that the main mode of mother-to-infant transmission may occur during delivery and their close contact after birth. |
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