| 丁正荣,李荣成,黄果勇,冯永贞,陈琨琳,农远志,苏启斌,安爱萍.原发性肝癌与乙型肝炎病毒病因关系的流行病学分析和探讨[J].Chinese journal of Epidemiology,1984,5(3):146-149 |
| 原发性肝癌与乙型肝炎病毒病因关系的流行病学分析和探讨 |
| Epidemiological Survey on The Etiological Relationship Between Primary Hepatocarcinoma and Hepatitis B Virus |
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| Abstract: |
调查肝癌高发区（隆安）8，799人和低发区26，242人，高发区HBsAg阳性率显著高于低发区，其中以0~9岁组为最高。高发区以1岁组，低发区以5岁组为HBsAg携带的年龄高峰，高发区在生命的早期即已受到HBV的高度感染。
对隆安携带者，非携带者1，042人进行了2~4年前瞻性观察，发现男性儿童HBsAg阴转率低，阳转率高。认为早期的HBsAg携带与以后的慢性肝病和肝癌高发有关。由配对和非配对追踪观察，发现HBsAg携带者发生肝癌的相对危险性较非携带者高4.29和6.7倍。认为乙型肝炎感染可能是导致肝癌的主要病因，而玉米黄曲霉毒素的污染和饮水污染不是肝癌发生的主要因素。 |
| English Abstract: |
| To determine the prevalence of HBsAg among residents in areas with high or low incidence of primary hepatocarcinoma, samples of serum were collected from 8,799 and 26,242 persons respectively. The HBsAg prevalence was found to be much higher in all age groups, especially in the group of 0~9 years of age in the area with high incidence of primary thepatocarcinoma (Longan County) than in that area with low incidence.The highest prevalence occured in one-year-old children in Longan County and in the group of 5 year olds in an area with low incidence.The present study showed that children in Longan were at high risk from a very early age.The prospective study data among 1,042 carriiers and non-carriers in the period of 2~4 years indicated that the HBsAg acquisition rate was significantly higher and the rate of HBsAg-becoming-negative was much lower in young age groups (below 10 years), especially males, than in older age groups. This suggested that a high incidence of primary hepatocarcinoma may be largely related to the early acquisition of HBV infection. Statistical analysis showed that the incidence of primary hepatocarcinoma in HBsAg carriers was much higher than in matched and unmatched controls. It was found that the relative risk for primary hepatocarcinoma in HBsAg carriers was 4.29 and 6.7 times higher than that in non-carriers.HBV infection was considered as a major etiological factor in the development of primary hepatocarcinoma.It was also found that corn contaminated with aflatoxin and contaminated water were not main factors for the development of primary hepatocarocinoma. |
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