| 鲍行豪,罗海波,张锦麟,李岩金,姜训,裘颖静.钩端螺旋体外膜菌苗的研究 Ⅳ 多价外膜菌苗小量人群实验接种的观察[J].Chinese journal of Epidemiology,1984,5(4):212-215 |
| 钩端螺旋体外膜菌苗的研究 Ⅳ 多价外膜菌苗小量人群实验接种的观察 |
| An Investigation of the Effect of Leptospiral Outer Envelope Vaccine——Ⅳ.A Study Among A Small Scale Population |
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| Abstract: |
| 钩端螺旋体外膜菌苗人体接种后反应轻微。免疫后1~3月抗体有明显增长。外膜菌苗一针注射即能达到或超过普通菌苗全程接种水平。一个月犬型及流感伤寒型抗体增长最高（t>3），黄疸出血型次之（t=1.9），秋季型较低（t=0.l）。三个月四型抗体均以外膜菌苗组高（t>2.5）。六个月两类菌苗抗体虽均明显下降，但仍以外膜菌苗组高（t>2.5）。 |
| English Abstract: |
| The side-effect of the Leptospiral outer envelope vaccine for human being was slight.One to three months after immunization,the serum antibody titer increased markedly. The average titre induced by a single dose injection of the outer envelope vaccine was as high as or even higher than that induced by whole cell vaccine.One month after vaccination,the antibodies against canicola serotype and grippotyphosa serotype ranked the highest (t>3), next was that against the icterohaem-orrhagiae serotype (t=1.9), the lowest was that agaist autumnalis serotype t (t=0.1). Three months after injection, in all 4 serotype antibodies, titers induced by the outer envelope vaccine were always higher than that by the whole cell vaccine (t>2.5). After six months, the antibody titers induced by both vaccines decreased, however, the former was still higher than the latter. |
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