| 王捷,韩萌,章幼妹,李鸿儒,柳坚,林翠芬,杨霞.用酶联免疫吸附试验进行疟疾血清流行病学调查[J].Chinese journal of Epidemiology,1985,6(2):74-77 |
| 用酶联免疫吸附试验进行疟疾血清流行病学调查 |
| Sero-epidemiological Survey of Malaria using ELISA Technique |
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| Abstract: |
| 用ELISA对海南岛疟疾仍在继续流行和爆发流行已被控制的两类地区的居民进行了血清流行病学的调查,在前者的原虫率为9.8%,ELISA的阳性率为35.2%。若按不同年龄组统计,则居民的抗体水平和原虫率出现一截然相反的图案,表明二者有着密切的联系。在后一类地区,爆发后的第2年。ELISA的阳性率明显高于前一类地区,居民的阳性率达72.2%,第4年时,虽原虫率变化不显,但平均抗体水平及阳性率均明显下降,25岁以下各年龄组已恢复至正常水平,表明一旦有传染源输入,仍有可能出现疟疾再流行。 |
| English Abstract: |
| ELISA with a soluble antigen of P. falciparum cultured in vitro was used for the sero-epidemiolo-gical survey of malaria in Hainan Island, Guang-Dong province. Fresh blood specimens were taken for detecting parasites and blood samples were tested on filter paper. Antibody level to malaria was expressed in optical density (OD) at 492 μm. Among the population in an endemic area, the parasite-carrier rate was 9.8% and the ELISA positive rate was 35.2%.The ELISA positive rate and parasite -carrierrate in different age groups ran in divergent ways.In an area where malaria was well controlled after an out break in 1977, the results of a survey in 1979 indicated that the ELISA positive rate amongst population was 72.2%. In 1981, the parasite-carrier rate changed from 1.7% to 2.1%, the ELISA positve rate and the malaria antibody level among the population decreased significantly. It is believed that once the source of malaria infection was introduced, another outbreak might occur. |
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