| 郝玉武.承德市寿王坟铜矿1,428人麻疹的血清学检测分析[J].Chinese journal of Epidemiology,1985,6(5):289-291 |
| 承德市寿王坟铜矿1,428人麻疹的血清学检测分析 |
| Seroepidemiology of Measles in 1428 People from a Copper Mine of Chengde City |
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| Abstract: |
| 在广泛使用MV18年后,对寿王坟铜矿1,428名18岁以下人群进行了麻疹HI抗体的检测。结果:1.平均HI抗体阳性率88.4%,GMTl:7.44.2.京55MV初免5年后抗体水平下降,免后7年成倍下降到初免前水平(70.5%、1:2.92),渴求再免。3.免后1~1.5个月GMT较免前高5.7倍(1:3.84→1:21.77).阳转率100%,≤ 1:16的4倍增长率平均为69.6%(21.1%~97.1%),免前滴度越低免后跳高率越高。4.实行计免后,麻疹平均年发病率较实行前下降95.较普种前下降99.1%,1979~83五年没有发现麻疹病例;流行中MV保护率为94.3%.5.病后免疫较人工自动免疫获得的抗体滴度高,恒定持久。据检测,笔者提出初免二针,1、2、8、14年龄组计划免疫方案的建议。 |
| English Abstract: |
After extensive use of MV for 18 years, the HI antibody of measles was tested in a population of 1428 individuals, less than 18 years of age, in Shou-wang-fen copper mine area. The results showed:
1. the overall HI antibody positive rate was 88.4%, GMT, 1:7.44.
2. 5 and 7 years after the first injection of vaccine B 55 MV, the titer dropped, especially in the latter use, even to the preimmunization (70.5%, l:2.92) level, and hence need reimmunization.
3.1-1.5 months after vaccination, there were a 5.7-fold increase (1:3.84→l:21.77) of GMT, will a conversion rate averaged 69.6% (21.1-97.1%). The lower preimmunization titer, the higher the conversion rate.
4.Since the beginning of the immunization project the measles incidence had decreased by 99.1% as compared with that 18 years before when measles vaccine was available.No measles occured during the period between 1979 and 1983.Protective rate of MV war 94.3%.
5. Immunity after attack of measles are lifelong and reached higher level than that of active immunization. Therefore, it is suggested that immunization should be groin, at 1, 2, 8 and 14 years of age. |
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