| 康庸,梅雅馨,孟令先,李祥,李颖,刘风云,巩志力,许健音,赵凯,王用辑,胡宗汉,宋珍珠.国产乙肝疫苗阻断e抗原阳性产妇HBV母婴传播的效果研究[J].Chinese journal of Epidemiology,1986,7(2):81-83 |
| 国产乙肝疫苗阻断e抗原阳性产妇HBV母婴传播的效果研究 |
| Study of the Efficacy of China-made Hepatitis “B” Viral Vaccine in Preventing Transmission of “e” Antigen from Mother to Her Infant |
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| Abstract: |
| 自1981年11月至1984年9月对51例HBsAg与HBeAg双阳性产妇之新生儿进行乙肝疫苗免疫观察,分两组:(1)接种组27例,乙肝血源疫苗系卫生部北京生物制品研究所提供。第一批18例用81-2批疫苗,蛋白含量为30μg/ml,免疫程序为0、1、3、6月肌注1.0毫升。第二批9例用83-1批疫苗,蛋白含量2 μg/ml,免疫程序为0、1、2、6月肌注1.0毫升。(2)对照组24例,观察结果:对照组婴儿24例中有22例HBsAg阳性,占91.67%,接种组27例中有3例HBsAg阳性,占11.11%,与对照组差别非常显著P<0.005,接种组保护率为87.8%。两批疫苗质量对比,83-1批优于81-2批。 |
| English Abstract: |
Immune response to HB vaccine of 51 neonates born of HBsAg and HBeAg positive mothers was observed in a period from Nov. 1981 to Sept. 1984
Twenty-Seven neonates were inoculated by HB vaccine which was produced by National Vaccine and Serum Institute Beijing.
In the first lot of neonates (18 cases), the vaccine (18-2 protein contains 30μ.g/ml 1.0ml) was given IM. within 24 hr. after birth and repeated at 1, 3 and 6 months.
In the second group neonates (9 cases) were inoculated by the vaccine (83-1 protein contains 20μg/ml) at 0, 1, 2, 6, months.
Control group contained 24 neonates born of HBsAg and HBeAg positive mothers.
The results showed HBsAg developed only in 3 of 27 vaccinated neonates (11.11%). This rate could be com pared with the carrier rate of 91.7 (22/24) in control group. The difference was statistically sig-nificant P<0.005 with protective efficacy 87.5%.
Comparing the lot 81-2 HBvaccine with the lot of 83-1 it is evident that latter is better than the former. |
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