| 李会庆,李天霖,张孔来,王天根.北京市城区女性乳腺癌某些危险因素的调查研究[J].Chinese journal of Epidemiology,1986,7(3):160-162 |
| 北京市城区女性乳腺癌某些危险因素的调查研究 |
| On the Risk Factors of Female Breast Cancers in the Urban District, Beijing |
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| Abstract: |
本文对北京四城区435例女性乳腺癌进行了1:1的病例对照研究。结果表明:不生育、初产年龄 ≥ 30岁、行经年数 ≥ 35年、月经紊乱、乳腺良性病史、乳腺肿瘤家族史、青春发育期胸部X线照射史、不幸的生活遭遇为乳腺癌的危险因素:而婚龄、哺乳期长、末次产龄、文化教育水平为混淆因素。在几个因素结合分析中看出初产龄 ≥ 30岁加月经紊乱有明显的协同作用。
本研究提出了在类似北京城区情况下选择乳腺癌高危险人群的四项指标:①初产龄 ≥ 30岁并有月经紊乱者;②不生育者;③有乳腺癌家族史者;④有乳腺组织增生或其它良性肿瘤病史者。应该定期对这些高危险人群进行防乳腺癌的普查。 |
| English Abstract: |
A case-control study was conducted among 435 women with breast cancer and 435 matched controls from patients' neighbours to investigate the risk factors for breast cancer in four districts of Beijing City.
The information gained was based on house to house interview. The average age-specific incidence and mortality rates in the above four districts of Beijing City during the period of Jan. 1, 1978 to Nov. 15, 1981 have been described. Variables in reproductive history were studied. The comparison between patients and controls showed significant differences in age at first birth, nullipara, number of children, years of menstruation and menstrual disorder.
Other variables concerning the risk of breast cancer were also studied. It included history of benign diseases of breast, family history of malignant breast diseases and history of exposure of breast to X-rays before twenty years of age.
Adjustment for potential confounding variables was carried out by means of stratification analysis and multiple regression model. The confounding variables were found to be related with lactation, age at marriage and last birth and education level.
The new discovery in the study was that theret was interaction (multiplied effect) between age a first birth (30 years of age) and menstrual disorder. EF (A×B)=0.75, 95% Confidence Interval=0.44-0.90. The indicators for high risk population were also described. |
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