| 胡希民,龚春梅,金玉才,肖才瑜,罗兰英,徐志雄.昆明市脊髓灰质炎活疫苗大规模免疫25年后人群抗体水平调查[J].Chinese journal of Epidemiology,1987,8(5):268-271 |
| 昆明市脊髓灰质炎活疫苗大规模免疫25年后人群抗体水平调查 |
| A Survey of Antibody Level among Population Massively Administrated Poliovaccine 25 Years Ago in Kunming City |
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| DOI： |
| KeyWord: 脊髓灰质炎活疫苗 中和试验 血清中和抗体 抗体百分率 几何平均滴度 |
| English Key Word: Live poliovaccine Neutralization test Serum neutralization antibody Percentage of antibodies Geometric mean titre |
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| Abstract: |
| 为了解昆明市大规模服用脊灰疫苗25年后人群的抗体水平,我们采集了昆明市区和郊区851名0~51岁健康人群血清和234份脐带血进行抗体水平调查。结果表明在健康人群中,I、II、III型抗体阳性率分别为74.9%,73.0%,65.0%;几何平均滴度为14.3,11.3,7.8。各型抗体阴性率为25%以上,大于12%的人群二个型或三个型抗体阴性,其中主要是≤1岁儿童。脊灰易感人群如此之高,实为值得注意的问题。今后应该采取相应措施,进一步加强督促计划免疫的实行,才能有效地控制和消灭脊灰的流行。 |
| English Abstract: |
| To evaluate the immune status after oral administration of poliovaccine in Kunming, the serum neutralizing antibody titers to poliovirus types I, II, and III were determined in 851 individuals and 234 samples of umbilical sera. The results showed that the positive rate of antibodies to poliovirus types I, II, and III were 74.9%, 73.0% and 65.0% respectively while Geometric mean titres were 14.3, 11.3 and 7.8. About 25% of tested sera to all three types of poliovirus were negative. More than 12% showed no neutralizing antibody to two or three types. Therefore it is important to take effective measures to control and eradicate poliomyelitis. |
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