阻断乙型肝炎母婴传播的初步研究

刘丽华; 刘正乐; 王宏禧; 汪新丽; 马凤鸣; 胡宗汉; 宋珍珠; 巩志立; 刘崇柏; 屠云人

Abstract

刘丽华,刘正乐,王宏禧,汪新丽,马凤鸣,胡宗汉,宋珍珠,巩志立,刘崇柏,屠云人.阻断乙型肝炎母婴传播的初步研究[J].Chinese journal of Epidemiology,1987,8(6):325-328

阻断乙型肝炎母婴传播的初步研究

Comparative Study of the Efficacy of Hepatitis B Virus (HBV) Vaccine Combined with Hepatitis B Immuno globulin (HBIG) Versus Vaccine Alone in the Interruption of the Perinatal Transmission of HBV Carrier State

DOI：

KeyWord: 乙型肝炎病毒乙肝e抗原乙肝疫苗母婴阻断

English Key Word: HBV HBeAg HBV Vacine Interruption Perinatal transmission

FundProject:

Author Name	Affiliation
Liu lihua	Sanitation and Anti-Epidemic Centre of Sichuan Province, West China University of Medical Sciences
et al	华西医科大学临床流行病教研室
王宏禧	Sanitation and Anti-Epidemic Centre of Sichuan Province, West China University of Medical Sciences
汪新丽	重庆市卫生防疫站
马凤鸣	成都市妇产科医院
胡宗汉	卫生部生物制品检定所
宋珍珠	卫生部生物制品检定所
巩志立	卫生部北京生物制品研究所
刘崇柏	中国预防医学科学院病毒所
屠云人	Sanitation and Anti-Epidemic Centre of Sichuan Province, West China University of Medical Sciences

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Abstract:

本文报告了四川地区阻断乙型肝炎母婴传播的研究结果。筛检孕妇HBsAg和HBeAg双阳性,或HBsAg阳性效价≥1:512的孕妇所产新生儿作为研究对象。80例新生儿按随机、双盲、安慰剂对照原则分成3组:疫苗组、疫苗加HBIG组和对照组。随访观察12个月时,乙肝感染保护率分别为88.0%和92.0%。认为国产乙肝疫苗和HBIG阻断乙肝母婴传播效果较好,单独疫苗接种效果亦较满意。

English Abstract:

A randomized double-blind placebo-controlled efficacy trial of HBV vaccine combined with HBIG versus vaccine alone for prevention of perinatal transmission of HBV was conducted in 80 infants born to HBsAg carrier mothers. All infants were followed for 12 months.
Efficacy was 92.0% and 88.0% respectively for the two immunization programmes.
This study demonstrated that a significant reduction of HBsAg carrier state was seen in infants recieving Chinese vaccine plus HBIG and that the vaccine was nearly equally efficacious even when given alone.

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