| 王敬良,杜福昌,王海燕,朱杰,姚才良,秦晓,邹志芬,董璜瑛,刘景明.冠心病危险因素五年前瞻性研究[J].Chinese journal of Epidemiology,1987,8(6):350-353 |
| 冠心病危险因素五年前瞻性研究 |
| A Five-year Prospective Study on Risk Factors in the Development of Coronary Heart Disease |
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| DOI： |
| KeyWord: 前瞻性研究 危险因素 多元逐步回归分析 冠心病猝死 冠心病 |
| English Key Word: Prospective study Risk factor Multivariate stepwise regression analysis Sudden coronary death Coronary heart disease |
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| Abstract: |
| 本文采用前瞻性方法,观察778名35岁以上人群,五年内冠心病发病率为5.19%,平均年发病率为1.04%。经多元逐步回归分析,筛选出心电图运动试验阳性、父母冠心病史、TG增高、平均血压增高、职业性精神紧张及TC增高等6个主要危险因素,进一步证实了以往回顾性调查的结果,并提出遗传及精神、神经因素在冠心病发病中也是不可忽视的因素。心电图运动试验阳性的意义视为预测指标,似较易患因素更为确切。 |
| English Abstract: |
This paper Presents the results of a five-year longitudinal prospective investigation on the incidence of first major coronary events and factors related to its development in a population of 778 persons aged 35 years or above by the multivariate stepwise regression analysis.
In the 5-year observation of the subjects 41 cases of coronary heart disease (CHD) occurred, including 4 myocardial infaction, one sudden coronary death and 36 angina pectoris. The total incidence of CHD in the 5 years period was 5.19%, making an average annual incidence of 1.04%.
According to the results of linear correlation and multivariate stepwise regression analysis, six major risk factors selected from 21 possible coronary risk factors were: positive double Master test, family CHD history, increased serum triglyceride value, occupational mental stress, elevation of arterial mean blood pressure and high total serum cholesterol level. In this study, the widely recognized influence of hypertension and hypercholesterolemia on the development of CHD in retrospective investigations was further confirmed. In addition, heredity and occupational mental stress were also the factors closely related to the development of CHD. As to the abnormal exercise ECG, we considered it would be a Predictable symbol rather than a risk factor of CHD |
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