| 鲁春起,陈捷,胡金泉,赵桂荣,丛珊珍,国耀忠.原发性肝癌与乙型肝炎关系的研究[J].Chinese journal of Epidemiology,1988,9(1):5-7 |
| 原发性肝癌与乙型肝炎关系的研究 |
| A Study of Correlation between Primary Hepatocellular Carcinoma and Hepatitis B |
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| DOI： |
| KeyWord: 原发性肝细胞癌 乙型肝炎病毒 乙型肝炎流行率 |
| English Key Word: Primary hepatocellular carcinoma Hepatitis B virus (HBV) Hepatitis B prevalence rate |
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| Abstract: |
| 本次调查对30例已确诊的PHC和30例其他肿瘤及肛肠外科病例对照,采用PHA和ELISA检测方法,做了1:2配对的血清流行病学调查。结果显示:PHC病例HBV流行率90%,HBsAg阳性率56.67%,抗-HBc阳性率33.33%,抗-HBe阳性率35.29%,均显著高于对照(P﹤0.05~0.001)。相对危险性也分别是对照组的7.6、5、39和5.5倍。通过询问还发现PHC病例的肝病史、肝炎接触史,也都显著高于对照(P﹤0.001)。从而进一步验证了HBV感染与PHC发病的病因学联系。 |
| English Abstract: |
| Thirty patients with primary hepatocellular carcinoma (PHC) and 60 controls with other tumour or ano-rectal diseases (1:2 matched) were tested for hepatitis B virus (HBV) markers with PHA and ELISA techniques. The re sults showed that HBsAg positive rate was 56.67%, anti-HBc 83.33%, anti-HBe 35.29% and HBVM 90% in the sera of PHC patients. All of them were significantly higher than that in controls (P<0.05-0.001). The odds ratios were 5, 39, 5.5, and 7.6 respectively. The proportions of those with history of liver disease and contact with hepatitis patients in PHC group were also significantly higher than that in control group (P<0.001). The results supported that the PHC was associated with HBV infections. |
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