| 吕宝成,韩雅儒,蒋玉英,冯福民,马俊荣,王长泰,王淑珍,田玉堂,杜德云.育龄期妇女风疹抗体筛检和免疫研究[J].Chinese journal of Epidemiology,1988,9(1):16-18 |
| 育龄期妇女风疹抗体筛检和免疫研究 |
| A Study on Rubella Antibody Screening and Immunization of Childbearing Age Women |
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| DOI： |
| KeyWord: 风疹抗体 筛检 免疫 |
| English Key Word: Rubella antibody Screening Immunity |
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| Abstract: |
| 1983~1986年在河北省承德市未婚女青年中进行了风疹HI抗体筛检和国产风疹减毒活疫苗(BRD Ⅱ株)免疫三年追踪研究。结果指出:535人抗体阴性率9.9%。用小样本免疫结果说明BRD Ⅱ株疫苗反应轻,近期抗体阳转率100%,几何均值180.82±2.19~140.50±1.97;免后三年追踪有12.5%的人阴转,几何均值降至37.33±2.44~31.75±2.58。本文提出了目前应采取婚前妇女免疫方案和以≥1:20作为临界免疫水平。 |
| English Abstract: |
| A study on rubella antibody screening and immunization of childbearing age women was carried out among 535 women in Chengde, Hebei Province, in 1983-1986. The results showed that the negative rate of rubella antiboty was 9.9% among those women. The HI geometric mean antibody (GMT) titer of those women was 33.93±2.70. This study also showed that the febrile rates of BRDⅡ20 and BRDⅡ31 vaccine were lower. Clinical reactions were much milder. 100% women had antibody response (four fold antibody rise) after vaccination and the GMT was ranged from 180.82±2.19 to 140.50±1.97. However, the antibody titer was decreased to <1:10 in three years after immunization in 16.7% of them and the GMT was decreased to 37.33±2.44 to 31.75±2.58. |
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