| 那英剑,胡孟璇.鼻咽癌病因学的病例—对照研究[J].Chinese journal of Epidemiology,1988,9(4):224-226 |
| 鼻咽癌病因学的病例—对照研究 |
| Case-Control Study on Nasopharyngeal Carcinoma |
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| DOI： |
| KeyWord: 鼻咽癌 病例—对照研究 多因素分析 |
| English Key Word: Nasopharyngeal carcinoma Case-control study Logistic regression |
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| Abstract: |
| 本文以病例—对照的方法探讨了在黑龙江省与鼻咽癌发生有关的危险因素。调查鼻咽癌病例及对照共127对。在单因素与条件Logistic回归分析中均表明幼儿期食咸鱼(OR=5.5, χ2=4.92, P<0.05)及长期生活在烧煤的环境中(OR=1.894, χ2=4.655, P<0.05)可能与鼻咽癌的发生有关。此外,条件Logistic回归分析还发现,鼻窦炎病史也可能与鼻咽癌的发生有联系(B=1.385, exp(B)=3,995, P<0.1)。在对病例及对照的一级亲属患恶性肿瘤情况的调查中发现,鼻咽癌病例组有肿瘤家族史者多于对照组,其差异有统计学意义(χ2=10.32, P<0.01)。 |
| English Abstract: |
In order to study the risk factors associated with nasopharyngeal carcinoma(NPC) in Hei Longjiang province, a casecontrol study on nasopharyngeal carcinoma was conducted in the Affiliated Tumour Hospital of Harbin Medical University, Hei Longjiang province, from January to December of 1985. Interviews with 127 cases and 127 matched controls were made.
Classical matched-pair statistic analysis and Logistic regression analysis were made with IBM PC/XT microcomputer. Results from the classical analysis indicated that salted fish consumption during childhood was a risk factor for nasopharyngeal carcinoma (relative risk 5.5; P<0.05). Exposure to soot was also significantly associated with this disease (odds ratio 1.9; P<0.05). They were similar to those from Logistic regression analysis. Genetic factors may also play a very important role in the Pathogenesis of nasopharyngeal carcinoma. In Logistic regression analysis, we found that the nasosinusitis was also as a significant risk factor in the development of NPC (B=1.38; exp (B)=3.99).
There was no association between nasopharyngeal carcinoma and fried food, pickled vegetables, tobacco, or alcohol etc. The sexsual difference in etiologic constitution was not found in the study either. |
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