脂蛋白胆固醇用于冠心病筛检试验的评价

李绍忱; 郝培良; 王束玫; 王永杰; 贾崇奇; 曹兆华; 高德恩

Abstract

李绍忱,郝培良,王束玫,王永杰,贾崇奇,曹兆华,高德恩.脂蛋白胆固醇用于冠心病筛检试验的评价[J].Chinese journal of Epidemiology,1989,10(3):167-171

脂蛋白胆固醇用于冠心病筛检试验的评价

The Evaluation of Lipoprotein as a Screening Test for Coronary Heart Disease

DOI：

KeyWord: 冠心病胆固醇

English Key Word: Coronary heart disease TC

FundProject:

Author Name	Affiliation
Li Shaochen	Dept. of Epidemiology, Shandong Medical University
郝培良	Dept. of Epidemiology, Shandong Medical University
王束玫	Dept. of Epidemiology, Shandong Medical University
王永杰	Dept. of Epidemiology, Shandong Medical University
贾崇奇	Dept. of Epidemiology, Shandong Medical University
曹兆华	山东医科大学附属医院心内科
高德恩	山东医科大学附属医院心内科

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Abstract:

至今尚无适于人群筛检冠心病的理想方法。38例心电图踏车运动试验阳性的病例组,与同期试验阴性的71例对照组进行筛检试验评价研究。选择TC/HDL-C、HDL-C/TC、LDL-C/HDL-C、HDL₂-C/HDL₃-C等比值为筛检指标,评价其不同界限值的真实性、预测值等。TC/HDL-C与HDL₂-C/HDL₃-C并联使用可以提高检出率达92%。多元逐步回归分析只有TC/HDL-C选入方程,计算其5个组段的阳性似然比,并以不同的验前概率拟代,结果验后概率以TC/HDL-C≥3.2最大,因此,国内"动脉粥样硬化指标"TC/HDL-C的界限值可定为≥3.2。

English Abstract:

Up to now there is no screening test suitable for coronary heart disease (CHD) among population. 38 cases of CHD diagnosed by electrocardiographic bicycle exercise and 71 cases with negative results as controls were studied concurrently to evaluate the screening test of CHD. According to the significant difference between the two groups, the ratio of TC/HDL-C、HDL-C/TC、LDL-C/HDL-C、HDL₂-C/HDL₃-C were selected to evaluate their validity and predictivity etc, on several cutoff vale respectively. TC/HDL-C and HDL₂-C/HDL₃-C were used in parallel to promote the detect ive value of CHD to 92%. TC/HDL-C was only selected in stepwise regression formula, so the positive likelihood of five-grade value of TC/HDL-C was calculated and different prior-test probability was estimated to predicte the post-test probability of CHD. As a result cutoff value 3.2 of TC/HDL-C could be determined as atherogenic index in chinese population.

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