乙型肝炎疫苗与婴儿期常用疫苗同时接种的免疫应答与反应观察:Ⅰ.乙型肝炎疫苗与白百破混合疫苗、脊髓灰质炎活疫苗同时接种的免疫应答与反应观察

袁承德; 迮文远; 杨进业; 李美娟; 苏万年; 杨宏徽; 刘保奎; 张国强; 董春明; 杜桂芝; 张国华; 王沼威; 黎国形; 何秀芳

Abstract

袁承德,迮文远,杨进业,李美娟,苏万年,杨宏徽,刘保奎,张国强,董春明,杜桂芝,张国华,王沼威,黎国形,何秀芳.乙型肝炎疫苗与婴儿期常用疫苗同时接种的免疫应答与反应观察:Ⅰ.乙型肝炎疫苗与白百破混合疫苗、脊髓灰质炎活疫苗同时接种的免疫应答与反应观察[J].Chinese journal of Epidemiology,1989,10(4):206-209

乙型肝炎疫苗与婴儿期常用疫苗同时接种的免疫应答与反应观察:Ⅰ.乙型肝炎疫苗与白百破混合疫苗、脊髓灰质炎活疫苗同时接种的免疫应答与反应观察

Immune Response and Reactions to Simultaneous Administration of Hepatitis B Vaccine with Routine Vaccine in ChildrenⅠ. Immune Response and Reactions to Simultaneous Administration of DPT, TOPV and Hepatitis B Vaccine

DOI：

KeyWord: 同时接种免疫应答白百破混合疫苗脊髓灰质炎活疫苗乙型肝炎疫苗

English Key Word: Simultaneous administration Japanese B encephalitis vaccine Measles vaccine Hepatitis B vaccine

FundProject:

Author Name	Affiliation
Yuan Chengde	National Vaccine and Serum Institute, Beijing
迮文远	National Vaccine and Serum Institute, Beijing
杨进业	广西壮族自治区卫生防疫站
李美娟	广西壮族自治区卫生防疫站
苏万年	National Vaccine and Serum Institute, Beijing
杨宏徽	广西壮族自治区卫生防疫站
刘保奎	National Vaccine and Serum Institute, Beijing
张国强	National Vaccine and Serum Institute, Beijing
董春明	National Vaccine and Serum Institute, Beijing
杜桂芝	National Vaccine and Serum Institute, Beijing
张国华	National Vaccine and Serum Institute, Beijing
王沼威	南宁市第三人民医院
黎国形	南宁市红会医院
何秀芳	南宁市红会医院

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Abstract:

本文对HB疫苗与DPT、TOPV疫苗同时接种的免疫应答性作了研究。对0~5月龄的229名婴儿随机分为Ⅰ组单独接种HB疫苗,Ⅱ组接种DPT、TOPV疫苗,Ⅲ组HB疫苗与DPT、TOPV同时接种。三针间隔为0、1、5个月,均作免前和第三针后一个月的血清抗体测定,同时接种组的抗-HBs、白喉、破伤风、百日咳及Ⅰ、Ⅱ、Ⅲ型OPV抗体的阳转率、GMT与单独接种组无差别。未见异常反应,一般反应均很轻微,二组间无差别。表明上述几种疫苗同时接种是安全和有效的。

English Abstract:

This paper reports the result of the immune response and reactions to simultaneous administration of Japanese B encephalitis vaccine, measles and hepatitis B vaccine. 215 children (0-9 months of age) were divided into three groups.Group one was vaccinated with hepatitis B vaccine alone, group two was uaccinated with Japanese B encephalitis vaccine, measles vaccine, and group three was Vaccinated with hepatitis B vaccine, Japanese B encephalitis vaccine and measles vaccine silmultaneously.
The result of the immune response to the combination of hepatitis B vaccine with Japanese B encephalitis vaccine were similer to that obseved after immunization with each vaccine alone.But the result of the immune response to the combination of hepatitis B vaccine with measles vaccine were lower than to that observed after immunization with measles vaccine alone.The general reaction of all vaccine were mild, no significant differeoce between each group was noted.
The study demonstrated that children can not be immunized with hepatitis B vaccine and measles vaccine simultaneously but can be immunized with hepatitis B Vaccine and Japanese B encephalitis vaccine.

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