乙型肝炎疫苗与婴儿期常用疫苗同时接种的免疫应答与反应观察:Ⅱ.乙型肝炎疫苗与乙型脑炎、麻疹疫苗同时接种的免疫应答与反应观察

袁承德; 迮文远; 杨进业; 李美娟; 苏万年; 杨宏徽; 刘保奎; 张国强; 董春明; 李淑云; 张国华; 王沼威; 黎国形; 何秀芳

Abstract

袁承德,迮文远,杨进业,李美娟,苏万年,杨宏徽,刘保奎,张国强,董春明,李淑云,张国华,王沼威,黎国形,何秀芳.乙型肝炎疫苗与婴儿期常用疫苗同时接种的免疫应答与反应观察:Ⅱ.乙型肝炎疫苗与乙型脑炎、麻疹疫苗同时接种的免疫应答与反应观察[J].Chinese journal of Epidemiology,1989,10(4):210-214

乙型肝炎疫苗与婴儿期常用疫苗同时接种的免疫应答与反应观察:Ⅱ.乙型肝炎疫苗与乙型脑炎、麻疹疫苗同时接种的免疫应答与反应观察

Immune Response and Reactions to Simultaneous Administration of Hepatitis B Vaccine With Routine Vaccine in Children II. Immune Response and Reactions to Simultaneous Administration of Hepatitis B Vaccine with Japanese B Encephalitis Vaccine and Measles Vaccine

DOI：

KeyWord: 同时接种乙型脑炎疫苗麻疹疫苗乙型肝炎疫苗

English Key Word: Simultaneoue administration Immune response DPT TOPV Hepatitis B vaccine

FundProject:

Author Name	Affiliation
Yuan Chengde	National Vaccine and Serum Institute, Beijing
迮文远	National Vaccine and Serum Institute, Beijing
杨进业	广西壮族自治区卫生防疫站
李美娟	广西壮族自治区卫生防疫站
苏万年	National Vaccine and Serum Institute, Beijing
杨宏徽	广西壮族自治区卫生防疫站
刘保奎	National Vaccine and Serum Institute, Beijing
张国强	National Vaccine and Serum Institute, Beijing
董春明	National Vaccine and Serum Institute, Beijing
李淑云	National Vaccine and Serum Institute, Beijing
张国华	National Vaccine and Serum Institute, Beijing
王沼威	南宁市第三人民医院
黎国形	南宁市红会医院
何秀芳	南宁市红会医院

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Abstract:

本文对HBV与JEV、MV同时接种的免疫应答性和反应作了研究。对0~9月龄215名婴儿随机分为Ⅰ组单独接种HBV,Ⅱ组分别接种JEV、MV,Ⅲ组HBV分别与MV、JEV同时接种,三针间隔为0、1、5个月。均作免前和免后的血清抗体测定,同时接种组的抗-HBs,JEV抗体的阳转率,GMT与单独接种无显著性差异,JEV抗体低于常规接种,MV的免疫应答性Ⅲ组低于Ⅱ组,有显著性差异。未见异常反应,一般反应均很轻微,二组间无差别,说明MV不宜与HBV同时接种,JEV不能用HBV免疫程序同时接种。

English Abstract:

This paper reports the result of the immune response and reactions to simultaneous administration of DPT, TOPV and hepatitis B vaccine. 180 children (0-5 months of age) were divided into three groups.Group one was vaccinated with hepatitis B vaccine alone, group two was vaccinated with DPT, TOPV vaccine, and group three was vaccinated with hepatitis B vaccine, DPT and TOPV vaccine simultaneously.
The result of the immune response to the combination of hepatitis B with DPT, TOPV vaccines were similar to that observed after immunization with each vaccine alone.The general reactions of all vaccines were mild, no significant difference between each group was noted
The study demonstrated that children can be immunized with hepatitis B vaccine and DPT, TOPV vaccines simultaneously.

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