| 李立,刘志良,刘文和,阎建平,严志平,付梓宾,廖寿恒,张月花,涂建宁,陈前进,曾贞元,郑金凤,苏用年,高霞献,包伟民,朱玉茂,徐林,李佛发.儿童计划免疫使用的“四苗”联合免疫的安全性及免疫应答研究[J].Chinese journal of Epidemiology,1989,10(4):215-218 |
| 儿童计划免疫使用的“四苗”联合免疫的安全性及免疫应答研究 |
| A Study on the Safty of Four Vaccines of Children EPI at the Same Time and the Results of the Immunological Responses after Vaccination |
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| DOI： |
| KeyWord: 联合免疫 临床反应 免疫应答 |
| English Key Word: Synthetic immunization Clinical reaction Immunological responses |
| FundProject: |
| Author Name | Affiliation | | Li Li | Anti-epidemic Station of Longyan District, Fujian Province | | 刘志良 | Anti-epidemic Station of Longyan District, Fujian Province | | 刘文和 | Anti-epidemic Station of Longyan District, Fujian Province | | 阎建平 | Anti-epidemic Station of Longyan District, Fujian Province | | 严志平 | Anti-epidemic Station of Longyan District, Fujian Province | | 付梓宾 | Anti-epidemic Station of Longyan District, Fujian Province | | 廖寿恒 | Anti-epidemic Station of Longyan District, Fujian Province | | 张月花 | Anti-epidemic Station of Longyan District, Fujian Province | | 涂建宁 | Anti-epidemic Station of Longyan District, Fujian Province | | 陈前进 | Anti-epidemic Station of Longyan District, Fujian Province | | 曾贞元 | 卫生部上海生物制品研究所 | | 郑金凤 | 福建省卫生防疫站 | | 苏用年 | 福建省卫生防疫站 | | 高霞献 | 福建省卫生防疫站 | | 包伟民 | 上杭县卫生防疫站 | | 朱玉茂 | 上杭县卫生防疫站 | | 徐林 | 上杭县卫生防疫站 | | 李佛发 | 卢丰乡卫生院 |
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| Abstract: |
| 本文报告了卡介苗(BCG)、百白破(DPT)、脊髓灰质炎三价活疫苗(TOPV)、麻疹活疫苗(MV)联合免疫(即在不同部位同时接种)的安全性及免疫应答研究的结果。现场将3~24月龄的337名初免儿童随机分为8组,系统观察疫苗接种的临床反应及免疫应答,肯定了四苗或三苗联合免疫与接种单苗的结果相似,即免疫后的临床反应轻微、免疫效果良好。联合免疫既能简化免疫程序,又可节省人力物力和经费开支,有较大的社会效益,尤其适宜于边远山区及少数民族地区推广。 |
| English Abstract: |
| The safty of the synthetic immunization of BCG, DPT, TOPV and MV and the results of studying on the immunological responses were reported. 337 preliminary immunized children of 3-24 month-age were voluntarily classified.The clinical reactions and the serological results of vaccination were systematically analysised.It was identified that the effect of the synthetic immunization of four vaccines or three vaccines was similar to that of the individnal immunization, i.e, the clinical reactions were slight and the effect was good after immunization.It was confirmed that the synthetic immunization could simplify the procedure of immunization and save manpower and cost.And it could solve the contradiction of the time space of vaccination, increase the vaccination coverage.It had conparative high social and economic benefit and fit for spreading in remote mountain area and minority nationality areas. |
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