| 刘丽娜,傅永潜,黄天卫,李春梅.肝硬化患者肠道菌群状态之初步探讨[J].Chinese journal of Epidemiology,1989,10(5):287-290 |
| 肝硬化患者肠道菌群状态之初步探讨 |
| Preliminary Study on Intestinal Microflora in Patients with Cirrhosis |
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| DOI： |
| KeyWord: 肝硬化 肠道菌群 |
| English Key Word: Cirrhosis Intestinal flora |
| FundProject: |
| Author Name | Affiliation | | Liu Lina | Department of Medicine, First Affiliated Hospital, Dalian Medical College, Dalian | | 傅永潜 | Department of Medicine, First Affiliated Hospital, Dalian Medical College, Dalian | | 黄天卫 | Department of Medicine, First Affiliated Hospital, Dalian Medical College, Dalian | | 李春梅 | Department of Medicine, First Affiliated Hospital, Dalian Medical College, Dalian |
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| Abstract: |
| 本文报吿62例肝硬化、14例肝炎患者和30例正常人的肠菌群定性与定量检查结果。观察到:肝硬化患者的粪便中厌氧菌总数、总活菌数、大肠杆菌、肠球菌、双歧杆菌、乳酸杆菌和梭菌菌数显著高于正常人和肝炎患者;新近发生过肝昏迷组肠球菌和梭菌数高于无肝昏迷组;肝功能损害较重组双歧杆菌数明显增高;但内毒素阳性组与阴性组的粪便中G-细菌量无显著差异。提示肝硬化患者存在肠菌群繁殖增多现象,肝功能损害程度与肠菌群量之间存在一定关系。 |
| English Abstract: |
| Intestinal microflora were studied in 62 patients with cirrhosis, 14 with hepatitis and 30 normal subjects.The fecal anaerobes, total viable organisms, E.coli, enterococcus, bifidobacterium, lactobocillus and clostridium were significantly greater in number in cirrhotic patients than in normal subjects and hepatitis. Significant increase in fecal enterococcus and clostridium was observed in the patients recently recovered from hepatic coma as compared with the patients without hepatic coma.Bifidobacterium was increased in cirrhotic patients with CCLI score above 9.No significant differece in fecal gram-negative organisms was observed between patients with or without LLT (+). These data suggest that there was a tendency of the intestinal microorganisms to be increased in cirrhotic patients and the existence of possible relationship between the severity of liver function impairment and quantity of intestinal flora. |
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