| 柯世荣,徐世美,张欣,张淑杰,李志仁.国产50微克乙肝血源疫苗免疫新生儿血清学效果研究[J].Chinese journal of Epidemiology,1990,11(6):331-333 |
| 国产50微克乙肝血源疫苗免疫新生儿血清学效果研究 |
| A Study on the Serological Effects of New born babies Using China Made 50μg Hepatitis B Vaccine |
| Received:March 16, 1989 Revised:October 05, 1989 |
| DOI： |
| KeyWord: 乙肝血源疫苗 血清学效果 |
| English Key Word: Hepatitis B vaccine Serological effect |
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| Abstract: |
| 应用卫生部北京生物制品研究所生产的乙肝血源疫苗,按出生后24小时内注射第一针30μg疫苗及1个月、6个月时注射第二、三针各10μg疫苗的方案免疫新生儿。全程免疫后1~6个月期间采集血清标本,用固相放射免疫试验检测HBsAg、抗-HBs和抗-HBc。共检测288名新生儿血清标本,HBsAg全部阴性;抗-HBs阳转率为96.18%,GMT为1105.14mIU/ml。结果表明国产50pg乙肝血源疫苗有良好的免疫原性,免疫新生儿获得满意的血清学效果。 |
| English Abstract: |
| The blood source Hepatitis B vaccine produced by Beijing Institute of Biological Products was given to New born babies. The procedeur and doses are as follows,first dose 30μg was given within 24 hours after birth; second dose 10μg was given one month after birth and the third dose 10μg was given 6 months after birth. The sera samples were collected during 1~6 months after 3 times of inoculation. And tested HBsAg, anti-HBs and anti-HBc by using Solid-phase Radioimmunoassay (SPRIA). In total, 288 sera samples were tested. All samples were negative in HBsAg; Positive rate of anti-HBs was 96.18.%, geometric titer was 1105.14mIU/m The results showed that the China made 50(ig Hepatitis B vaccine has a good serological effect on newborn babies. |
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